Sodium Chloride Injection

Sodium chloride is an electrolyte supplement. Sodium and chloride are important electrolytes in the body, mainly existing in extracellular fluid, and play a very important role in maintaining normal blood and extracellular fluid volume and osmotic pressure. The normal serum sodium concentration is 135-145mmol/L, accounting for 92% of plasma cations and 90% of total osmotic pressure, so the plasma sodium content plays a decisive role in osmotic pressure. The normal serum chloride concentration is 98-106mmol/L. Sodium and chloride ions in the human body are mainly regulated by the hypothalamus, posterior pituitary and kidneys to maintain the stability of body fluid volume and osmotic pressure.

This product is an isotonic sterilized aqueous solution of sodium chloride. The sodium chloride (NaCl) content should be 0.850% to 0.950% (g/ml).

This product is a colorless, clear liquid with a slightly salty taste.

Water loss due to various reasons, including hypotonic, isotonic and hypertonic water loss; hyperosmotic non-ketotic diabetic coma, the use of isotonic or hypotonic sodium chloride can correct water loss and hyperosmotic state; hypochloremic metabolic alkalosis; external use of normal saline to rinse eyes, wash wounds, etc.; also used for obstetric water bag induction of labor.

1 Hypertonic dehydration: When hypertonic dehydration occurs, the osmotic concentration of brain cells and cerebrospinal fluid increases. If the treatment causes the sodium concentration and osmotic concentration of plasma and extracellular fluid to drop too quickly, brain edema may occur. Therefore, it is generally believed that within 48 hours after the start of treatment, the plasma sodium concentration should not drop by more than 0.5mmol/L per hour. If the patient is in shock, sodium chloride injection should be given first, and colloid should be supplemented as appropriate. When the shock is corrected, the blood sodium is 155mmol/L, and the plasma osmotic concentration is 350mOsm/L, 0.6% hypotonic sodium chloride injection can be given. When the plasma osmotic concentration is <330mOsm/L, 0.9% sodium chloride injection should be used instead. The total amount of fluid replacement is calculated according to the following formula for reference: The required amount of fluid replacement (L) = [blood sodium concentration (mmol/L) - 142] × 0.6 × body weight (Kg) ÷ blood sodium concentration (mmol/L). Generally, half of the amount is replenished on the first day, and the rest is replenished within the next 2-3 days, and it is adjusted according to the cardiopulmonary and renal function. 2 Isotonic dehydration: In principle, isotonic solutions are given, such as 0.9% sodium chloride injection or compound sodium chloride injection, but the chloride concentration of the above solutions is significantly higher than that of plasma. Large-scale use alone can cause hyperchloremia, so 0.9% sodium chloride injection and 1.25% sodium bicarbonate or 1.86% (1/6M) sodium lactate can be prepared in a ratio of 7:3 and then replenished. The latter has a chloride concentration of 107mmol/L and can correct metabolic acidosis. The amount of replenishment can be calculated by body weight or hematocrit for reference. ① Calculated by body weight: fluid replacement (L) = (weight loss (kg) × 142)/154; ② Calculated by hematocrit: fluid replacement (L) = (actual hematocrit - normal hematocrit) × body weight (kg) × 0.2/normal hematocrit. Normal hematocrit is 48% for males and 42% for females. 3 Hypotonic dehydration: In severe hypotonic dehydration, the solutes in brain cells decrease to maintain cell volume. If the treatment causes the plasma and extracellular fluid sodium concentration and osmotic concentration to rise rapidly, brain cell damage may occur. It is generally believed that when blood sodium is lower than 120mmol/L, the treatment causes the blood sodium to rise at a rate of 0.5mmol/L per hour, not exceeding 1.5mmol/L per hour. When blood sodium is lower than 120mmol/L or when central nervous system symptoms occur, 3%-5% sodium chloride injection can be given by slow drip. It is generally required to increase blood sodium concentration to above 120mmol/L within 6 hours. Sodium supplementation (mmol) = [142-actual blood sodium concentration (mmol/L)] × body weight (kg) × 0.2. When blood sodium rises to above 120-125mmol/L, isotonic solution can be used instead or hypertonic glucose injection or 10% sodium chloride injection can be added to isotonic solution as appropriate. 4 Hypochloremic alkalosis: Give 0.9% sodium chloride injection or compound sodium chloride injection (Ringer's solution) 500-1000ml, and the dosage will be determined according to the alkalosis condition. 5 For external use, wash the wound and rinse the eyes with physiological sodium chloride solution.

1. Too much or too fast infusion can cause water and sodium retention, resulting in edema, increased blood pressure, increased heart rate, chest tightness, dyspnea, and even acute left heart failure. 2. Too much or too fast administration of hypotonic sodium chloride can cause hemolysis, cerebral edema, etc.

Contraindicated in pregnancy induced hypertension.

When used as a drug solvent or diluent, attention should be paid to incompatibilities between drugs.

Keep tightly closed.

100 ml: 0.9 g

HUA-YU (WUXI) Pharmaceutical Co., Ltd.

• Founded in:

  1993-01-19

• Address:

  2nd Floor, Building 7, Phase II, Biomedical R&D Service Outsourcing Zone, No. 138 Meiliang Road, Mashan, Wuxi

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  91320200607912858J

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  $20 million

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