Methylene Blue Injection

Methylene blue itself is an oxidant, and it has two different effects on hemoglobin depending on its concentration in the body. At low concentrations, hydrogen ions in the dehydrogenation process of 6-phosphate-glucose are transferred to methylene blue through reduced triphosphate pyridine nucleoside, converting it into reduced white methylene blue; white methylene blue then transfers hydrogen ions to methemoglobin with trivalent iron, reducing it to normal hemoglobin with divalent iron, and white methylene blue is oxidized to methylene blue. The reduction-oxidation process of methylene blue can be repeated. At high concentrations, methylene blue cannot be completely reduced to white methylene blue, so it has an oxidizing effect, oxidizing normal hemoglobin to methemoglobin. Since methemoglobin easily combines with CN- to form cyanomethemoglobin, but the two dissociate again after a few minutes, it can only temporarily inhibit the toxicity of CN- to tissue poisoning.

Methylene blue. Chemical name: 3,7-bis(dimethylamino)phenothiatin-5-ium chloride trihydrate.

This product is a dark blue clear liquid.

This product is effective for methemoglobinemia caused by chemicals such as nitrite, nitrate, aniline, nitrobenzene, trinitrotoluene, benzoquinone, phenylhydrazine, etc. and drugs containing or producing aromatic amines (acetanilide, acetaminophen, phenacetin, benzocaine, etc.). It is less effective for methemoglobinemia caused by congenital reduced diphosphate pyridine nucleoside methemoglobin reductase deficiency. It is ineffective for abnormal hemoglobin M accompanied by methemoglobinemia. It can temporarily delay the toxicity of acute cyanide poisoning.

Intravenous injection: 1-2 mg/kg of body weight for nitrite poisoning, 5-10 mg/kg of body weight for cyanide poisoning, and the maximum dose is 20 mg/kg.

Intravenous injection of this product too quickly can cause dizziness, nausea, vomiting, chest tightness, abdominal pain, and excessive dosage. In addition to the aggravation of the above symptoms, headaches, lowered blood pressure, increased heart rate with arrhythmia, profuse sweating and impaired consciousness may also occur. After taking the drug, the urine will be blue and there may be stinging pain in the urethra during urination.

Not yet clear.

Precautions for children: 1. Cyanide poisoning: 10 mg/kg once, add 20-40 ml of 5% glucose injection, slowly intravenously inject. Until the cyanosis around the mouth disappears, then give sodium thiosulfate. 2. Nitric acid and nitrite poisoning: 1-2 mg/kg once, slowly intravenously inject (more than 5-10 minutes). Precautions for pregnancy and lactation: This experiment has not been conducted and there is no reliable reference. Precautions for the elderly: This experiment has not been conducted and there is no reliable reference.

Not yet clear.

Keep away from light and store in a sealed container.

2 ml: 20 mg

36 months

Jumpcan Pharmaceutical Group Co., Ltd.

• Founded in:

  1994-05-03

• Address:

  Baota Bay, Daqing West Road, Taixing City

• Tax NO.:

  913212831411793153

• Registered Funds:

  300 million yuan

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