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Compound Tropicamide Eye Drops

Function and Efficacy

This product is composed of tropicamide and phenylephrine hydrochloride. Tropicamide has atropine-like parasympathetic nerve inhibitory effect, which can cause mydriasis and accommodation paralysis after drug absorption, while phenylephrine hydrochloride has sympathetic nerve excitatory effect, which manifests as mydriasis and local vasoconstriction after absorption.

Ingredients

Each bottle contains 25 mg of tropicamide and 25 mg of phenylephrine hydrochloride.

Name Description Content CAS NO. Manufacturer
TropicamideIngredients

It has atropine-like parasympathetic inhibitory effect, and can cause mydriasis and accommodation paralysis after drug absorption

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1508-75-4 16
(R)-Phenylephrine HydrochloridIngredients

It has a sympathetic nerve excitatory effect, and after absorption, it manifests as mydriasis and local vasoconstriction

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61-76-7 34

Appearance

This product is a colorless or slightly yellow clear liquid.

Usage and Dosage

Generally, 0.5% tropicamide and 0.5% phenylephrine hydrochloride mixed eye drops are commonly used in clinical practice. The combination of the two drugs has a synergistic mydriasis effect, reduces the dosage of the drug and reduces adverse reactions. 1. Mydriasis examination: This product is dripped into the conjunctival sac, 1 drop at a time, and the second drop is dripped after an interval of 5 minutes. This product begins to dilate the pupil 5 to 10 minutes after eye drops, and the pupil is dilated to the maximum in 15 to 20 minutes. After about an hour and a half, the pupil begins to shrink, and the pupil returns to the level before the drop of the drug in 5 to 10 hours. 2. Refractive examination: Use this product to drip into the eye once every 5 minutes, for 4 consecutive drops, and a refractive examination can be performed after 20 minutes. Considering the existence of residual accommodation, it is not suitable for mydriasis optometry for children under 12 years old.

Adverse Reactions

Occasionally, local eye irritation symptoms may occur. It may also cause a temporary slight increase in intraocular pressure in patients with open-angle glaucoma, but since phenylephrine itself has the effect of lowering intraocular pressure, it will not cause damage to the optic nerve.

Precautions

1. It is contraindicated for patients with angle-closure glaucoma who have not undergone surgery. 2. It should be used with caution in children.

Special Population Medication

Precautions for children: Use with caution in children. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.

Drug Interactions

Concomitant use with monoamine oxidase inhibitors or tricyclic antidepressants can cause a significant increase in blood pressure.

Storage

Keep away from light, tightly closed, in a cool place.

Packaging Specification

5ml: Tropicamide 25mg, Phenylephrine Hydrochloride 25mg

Validity Period

18 months

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