Compound Tropicamide Eye Drops
Function and Efficacy
This product is composed of tropicamide and phenylephrine hydrochloride. Tropicamide has atropine-like parasympathetic nerve inhibitory effect, which can cause mydriasis and accommodation paralysis after drug absorption, while phenylephrine hydrochloride has sympathetic nerve excitatory effect, which manifests as mydriasis and local vasoconstriction after absorption.
Ingredients
Each bottle contains 25 mg of tropicamide and 25 mg of phenylephrine hydrochloride.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| TropicamideIngredients |
It has atropine-like parasympathetic inhibitory effect, and can cause mydriasis and accommodation paralysis after drug absorption More |
1508-75-4 | 16 | |
| (R)-Phenylephrine HydrochloridIngredients |
It has a sympathetic nerve excitatory effect, and after absorption, it manifests as mydriasis and local vasoconstriction More |
61-76-7 | 34 |
Appearance
This product is a colorless or slightly yellow clear liquid.
Indication
Mydriatic drugs. Mydriatic and accommodative paralytic drugs for examination.
Usage and Dosage
Generally, 0.5% tropicamide and 0.5% phenylephrine hydrochloride mixed eye drops are commonly used in clinical practice. The combination of the two drugs has a synergistic mydriasis effect, reduces the dosage of the drug and reduces adverse reactions. 1. Mydriasis examination: This product is dripped into the conjunctival sac, 1 drop at a time, and the second drop is dripped after an interval of 5 minutes. This product begins to dilate the pupil 5 to 10 minutes after eye drops, and the pupil is dilated to the maximum in 15 to 20 minutes. After about an hour and a half, the pupil begins to shrink, and the pupil returns to the level before the drop of the drug in 5 to 10 hours. 2. Refractive examination: Use this product to drip into the eye once every 5 minutes, for 4 consecutive drops, and a refractive examination can be performed after 20 minutes. Considering the existence of residual accommodation, it is not suitable for mydriasis optometry for children under 12 years old.
Adverse Reactions
Occasionally, local eye irritation symptoms may occur. It may also cause a temporary slight increase in intraocular pressure in patients with open-angle glaucoma, but since phenylephrine itself has the effect of lowering intraocular pressure, it will not cause damage to the optic nerve.
Precautions
1. It is contraindicated for patients with angle-closure glaucoma who have not undergone surgery. 2. It should be used with caution in children.
Special Population Medication
Precautions for children: Use with caution in children. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.
Drug Interactions
Concomitant use with monoamine oxidase inhibitors or tricyclic antidepressants can cause a significant increase in blood pressure.
Storage
Keep away from light, tightly closed, in a cool place.
Packaging Specification
5ml: Tropicamide 25mg, Phenylephrine Hydrochloride 25mg
Validity Period
18 months