Epalrestat Tablets
Function and Efficacy
Epalrestat is a reversible non-competitive inhibitor of aldose reductase, which has a selective inhibitory effect on aldose reductase. Clinical studies have shown that epalrestat can inhibit the accumulation of sorbitol in erythrocytes of patients with diabetic peripheral neuropathy, and can improve the subjective symptoms and neurological dysfunction of patients compared with the control group. Animal experiments have shown that epalrestat can significantly inhibit the accumulation of sorbitol in the sciatic nerve, erythrocytes, and retina of diabetic model rats, and improve their motor nerve conduction velocity and autonomic nerve function; in terms of neuromorphology, epalrestat can improve axonal flow abnormalities, increase the density of myelinated nerve fibers in the sciatic nerve, the thickness of the myelin sheath of the sural nerve, the axon area, and the axon cylindrical rate; in addition, epalrestat can also improve the blood flow of the sciatic nerve of the model animal and restore its inositol content.
Ingredients
Active ingredient: Epalrestat.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| EpalrestatIngredients |
Epalrestat is a reversible non-competitive inhibitor of aldose reductase, which has a selective inhibitory effect on aldose reductase. Clinical studies have shown that epalrestat can inhibit the accumulation of sorbitol in erythrocytes of patients with diabetic peripheral neuropathy, and can improve the subjective symptoms and neurological dysfunction of patients compared with the control group. Animal experiments have shown that epalrestat can significantly inhibit the accumulation of sorbitol in the sciatic nerve, erythrocytes, and retina of diabetic model rats, and improve their motor nerve conduction velocity and autonomic nerve function; in terms of neuromorphology, epalrestat can improve axonal flow abnormalities, increase the density of myelinated nerve fibers in the sciatic nerve, the thickness of the myelin sheath of the sural nerve, the axon area, and the axon cylindrical rate; in addition, epalrestat can also improve the blood flow of the sciatic nerve of the model animal and restore its inositol content. More |
82159-09-9 | 18 |
Appearance
This product is a brown film-coated tablet, which appears orange-red after removing the film coating.
Indication
Diabetic neuropathy.
Usage and Dosage
The usual dose for adults is 50 mg (1 tablet) three times a day, taken orally before meals.
Adverse Reactions
1 Allergy: Occasionally erythema, blisters, rash, itching. 2 Liver: Occasionally elevated bilirubin, AST, ALT, r-GTP. 3 Digestive system: Occasionally diarrhea, nausea, vomiting, abdominal pain, loss of appetite, abdominal distension, stomach discomfort. 4 If allergic symptoms occur, the drug should be discontinued immediately and appropriate treatment should be given. 5 Patients who have not seen any effect from taking this product for 12 consecutive weeks should consider switching to other treatments.
Precautions
Not to be used by pregnant or lactating women.
Special Population Medication
Precautions for children: There is no experience on the safety of medication for children. Precautions for pregnancy and lactation: There is currently no safety data for this product in pregnant women. Therefore, pregnant women should be extremely cautious when using this product and weigh the pros and cons before deciding whether to use it. Animal experiments have shown that this product can be excreted through breast milk. Therefore, breastfeeding women should avoid using this product. Precautions for the elderly: Elderly patients should consider appropriate reductions when using this product due to changes in physiological functions.
Drug Interactions
Not yet clear.
Storage
Store in a sealed container at room temperature away from light.
Packaging Specification
50mg
Validity Period
18 months.
Manufacturer
Shandong Dyne Marine Organism Pharmaceutical Co., Ltd.
-
Founded in:
1994-10-27 -
Address:
No. 18, Fuyuan South Road, Rongcheng City, Shandong Province -
Tax NO.:
913700006137729862 -
Registered Funds:
62 million yuan -
Website:
-
Email: