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Galantamine Hydrobromide Dispersible Tablets

Function and Efficacy

According to literature reports, this product is an anticholinesterase drug that can pass through the blood-brain barrier. Efficacy tests have shown that this product has a promoting effect on the acquisition of passive avoidance operations in mice, and has a significant improvement on the memory consolidation disorders caused by scopolamine and sodium nitrite; it has a good promoting effect on the learning and memory reproduction of light and dark discrimination operations in rats.

Ingredients

Chemical name: The main chemical component is galanthamine hydrobromide, and its chemical name is: 11-methyl-3-methoxy-4a,5,9,10,11,12-hexahydro-6H-benzofuran[3a,3,2-ef][2]benzazepine-6-ol hydrobromide. Chemical structure: Molecular formula: C17H21NO3·HBr Molecular weight: 368.27

Name Description Content CAS NO. Manufacturer
Galantamine HydrobromideIngredients

Anticholinesterase drugs can pass through the blood-brain barrier, promote the acquisition of passive avoidance operation in mice, and significantly improve the memory consolidation disorders caused by scopolamine and sodium nitrite; they have a good promoting effect on the learning and memory reproduction of light and dark discrimination operation in rats.

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1953-04-4 18

Appearance

This product is white or off-white tablets.

Indication

It is suitable for benign memory disorders and improves patients' ability of directed memory, associative learning, image recall, meaningless pattern recognition and portrait recall. It also has an improving effect on memory disorders caused by dementia patients and organic brain lesions.

Usage and Dosage

Oral administration, 5 mg (one tablet) at a time, 4 times a day. After three days, change to 10 mg (two tablets) at a time, 4 times a day, or as directed by a doctor.

Adverse Reactions

1. Nervous system: common symptoms include fatigue, dizziness, headache, tremor, insomnia, and dreaminess. Rare symptoms include hypertonia, paresthesia, aphasia, and hyperkinesia. 2. Gastrointestinal system: abdominal distension, nausea, vomiting, abdominal pain, diarrhea, anorexia, weight loss, and indigestion are common. There are also reports of dysphagia and gastrointestinal bleeding. 3. Cardiovascular system: bradycardia and arrhythmia may be seen. Hypotension is rare. 4. Blood system: anemia may be seen, and thrombocytopenia may occur occasionally. 5. Endocrine and metabolic system: hyperglycemia may occur occasionally, and hypokalemia has been reported.

Precautions

1. It is contraindicated for patients who are allergic to any of the ingredients in this product. 2. Galantamine is a cholinesterase inhibitor and is contraindicated under anesthesia. 3. It is contraindicated for patients with angina pectoris and bradycardia. 4. It is contraindicated for patients with severe asthma or pulmonary dysfunction. 5. It is contraindicated for patients with severe liver damage. 6. It is contraindicated for patients with severe kidney damage. 7. It is contraindicated for patients with mechanical intestinal obstruction, urinary tract obstruction or bladder surgery recovery period.

Special Population Medication

Precautions for children: There is no research information and data on the use of galantamine in children, so it is not recommended for children to use this product. Precautions for pregnancy and lactation: 1. There is no data on pregnant women taking this product, so pregnant women should weigh the pros and cons when taking it. 2. It is not clear whether this product is excreted from breast milk, and there is no research data on breastfeeding women, so it is not recommended for breastfeeding women to use this product. Precautions for the elderly: Refer to the content under other items or follow the doctor's advice.

Drug Interactions

1. This product has the potential to weaken the therapeutic effect of anticholinergic drugs. 2. It has a synergistic effect when used in combination with cholinergic agents and other cholinesterase inhibitors. 3. This product can be used in combination with cimetidine and ketoconazole to increase its bioavailability. 4. It can be used in combination with erythromycin to reduce the efficacy of this product. 5. There are reports of atrioventricular conduction block when this product is used in combination with digoxin.

Storage

Keep in a sealed container and away from light.

Packaging Specification

5mg

Validity Period

Tentative 24 months

Manufacturer

Beijing Eastern Union Biopharmaceuticals, Ltd.

  • Founded in:

    2001-01-17
  • Address:

    No. 17, Zhonghe Street, Beijing Economic and Technological Development Zone, Beijing
  • Tax NO.:

    911103028011490830
  • Registered Funds:

    $9.8 million
  • Email:

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