Potassium Chloride Granules
Function and Efficacy
Potassium is the main cation in cells, with a concentration of 150-160 mmol/L, while the main cation outside cells is sodium ions, with a potassium concentration of only 3.5-5.0 mmol/L. The body mainly relies on Na+, K+, and ATPase on the cell membrane to maintain the difference in K+ and Na+ concentrations inside and outside cells. The acid-base balance in the body has an impact on potassium metabolism. For example, when acidosis occurs, H enters the cell. In order to maintain the potential difference inside and outside the cell, K+ is released outside the cell, causing or aggravating hyperkalemia. Metabolic disorders can also affect acid-base balance. The normal potassium ion concentration and concentration difference inside and outside cells are closely related to certain functions of cells, such as carbohydrate metabolism, glycogen storage and protein metabolism, excitability and conductivity of nerves and muscles including myocardium, etc.
Ingredients
The main ingredient is potassium chloride.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Potassium chlorideIngredients |
Potassium is the main cation in cells, with a concentration of 150-160 mmol/L, while the main cation outside cells is sodium ions, with a potassium concentration of only 3.5-5.0 mmol/L. The body mainly relies on Na+, K+, and ATPase on the cell membrane to maintain the difference in K+ and Na+ concentrations inside and outside cells. The acid-base balance in the body has an impact on potassium metabolism. For example, when acidosis occurs, H enters the cell. In order to maintain the potential difference inside and outside the cell, K+ is released outside the cell, causing or aggravating hyperkalemia. Metabolic disorders can also affect acid-base balance. The normal potassium ion concentration and concentration difference inside and outside cells are closely related to certain functions of cells, such as carbohydrate metabolism, glycogen storage and protein metabolism, excitability and conductivity of nerves and muscles including myocardium, etc. More |
7447-40-7 | 39 |
Appearance
This product is white or slightly yellow granules.
Indication
Treat hypokalemia.
Usage and Dosage
Oral potassium salts are used to treat mild hypokalemia or as preventive medication. The usual dose for adults is 0.5-1g (6.7-13.4mmol) each time, dissolved in warm water and taken 1-3 times a day, after meals, and the dose is adjusted according to the condition. The maximum daily dose for adults is 6g (80mmol).
Adverse Reactions
1. Oral administration may cause gastrointestinal irritation symptoms, such as nausea, vomiting, throat discomfort, chest pain (esophageal irritation), abdominal pain, diarrhea, and even peptic ulcer and bleeding. This is more likely to occur when the patient is fasting, taking a large dose, or has existing gastrointestinal diseases. 2. Patients with existing renal impairment should be aware of the occurrence of hyperkalemia.
Precautions
Contraindicated in patients with hyperkalemia.
Special Population Medication
Precautions for children: Not clear. Precautions for pregnancy and lactation: No special precautions. Precautions for the elderly: The kidneys of the elderly have reduced K+ clearance function, and hyperkalemia is more likely to occur when potassium salts are used.
Drug Interactions
1. Adrenal glucocorticoids, especially those with more obvious mineralocorticoid effects, adrenal mineralocorticoids and adrenocorticotropic hormone (ACTH), can promote urinary potassium excretion, and when used together, the efficacy of potassium salts is reduced. 2. Anticholinergic drugs can aggravate the gastrointestinal irritation of oral potassium salts, especially potassium chloride. 3. Non-steroidal anti-inflammatory analgesics aggravate the gastrointestinal reactions of oral potassium salts. 4. When stored blood (30mmol/L of potassium for less than 10 days of storage, 65mmol/L for more than 10 days of storage), potassium-containing drugs and potassium-sparing diuretics are used together, the chance of hyperkalemia increases, especially in patients with renal damage. 5. Angiotensin-converting enzyme inhibitors and cyclosporine A can inhibit aldosterone secretion and reduce urinary potassium excretion, so hyperkalemia is prone to occur when used together. 6. Heparin can inhibit the synthesis of aldosterone and reduce urinary potassium excretion, so hyperkalemia is prone to occur when used together. In addition, heparin can increase the chance of gastrointestinal bleeding. 7. Sustained-release potassium salt can inhibit the intestinal absorption of vitamin B12.
Storage
Keep tightly closed.
Packaging Specification
10g:1.5g
Validity Period
24 months
Manufacturer
-
Founded in:
1997-07-21 -
Address:
No. 100, Xingguang Avenue, Renhe Town, Yubei District, Chongqing -
Tax NO.:
91500000202851807X -
Registered Funds:
196.54 million yuan -
Website:
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Email: