Indapamide Tablets

It is a sulfonamide diuretic that works by inhibiting the reabsorption of water and electrolytes in the dilution segment of the distal renal tubular cortex. The antihypertensive mechanism is unknown, and its diuretic effect cannot explain the antihypertensive effect, because the dose at which the antihypertensive effect occurs is much smaller than the dose of the diuretic effect. Possible mechanisms include the following aspects: regulating calcium influx into vascular smooth muscle cells; stimulating the synthesis of prostaglandins PGE2 and prostaglandins PGI2; reducing the hypersensitivity of blood vessels to vasopressor amines, thereby inhibiting vasoconstriction. This product has little or no effect on cardiac output, heart rate and heart rhythm when lowering blood pressure. Long-term use of this product rarely affects glomerular filtration rate or renal blood flow. This drug does not affect the metabolism of blood lipids and carbohydrates.

The main ingredient of this product is indapamide, and its chemical name is N-(2-methyl-2,3-dihydro-1H-indolyl)-3-sulfamoyl-4-chloro-benzamide.

This product is a sugar-coated tablet, which appears white after removing the sugar coating.

Used to treat hypertension. Mainly used to treat mild and moderate hypertension, and has a good effect on renal hypertension and diabetic hypertension.

The usual oral dose for adults is 2.5 mg (1 tablet) once a day.

Relatively mild and short-lived, and dose-related. 1 Less common are: diarrhea, headache, loss of appetite, insomnia, nausea, orthostatic hypotension. 2 Less common are: allergic reactions such as rash and itching; hyponatremia, hypokalemia, and hypochloremic alkalosis.

Allergic to sulfonamides, severe renal insufficiency, hepatic encephalopathy or severe hepatic insufficiency, hypokalemia.

Precautions for children: Not clear yet. Precautions for pregnancy and lactation: There is no human research on the effect on pregnancy, and no problems have been found in animal studies. It is not clear whether this product is excreted into breast milk, but no problems have occurred in human use. Precautions for the elderly: The elderly are more sensitive to antihypertensive effects and electrolyte changes, and often have changes in renal function, so caution should be exercised when using this product.

1. When this product is used together with adrenal cortical hormone, the diuretic and natriuretic effects are weakened. 2. When this product is used together with amiodarone, it is easy to cause arrhythmia due to low blood potassium. 3. When this product is used together with oral anticoagulants, the anticoagulant effect is weakened. 4. When this product is used together with non-steroidal anti-inflammatory analgesics, the natriuretic effect of this product is weakened. 5. When this product is used together with dopamine, the diuretic effect is enhanced. 6. When this product is used together with other types of antihypertensive drugs, the antihypertensive effect is enhanced. 7. When this product is used together with sympathomimetics, the antihypertensive effect is weakened. 8. When this product is used together with lithium agents, the blood lithium concentration may increase and signs of overdose may appear. 9. When used together with large doses of salicylates, patients who have been dehydrated may develop acute renal failure. 10. When used together with metformin, lactic acidosis is likely to occur.

Keep in a light-proof and airtight container.

2.5mg

24 months.

Yaopharma Co., Ltd.

• Founded in:

  1997-07-21

• Address:

  No. 100, Xingguang Avenue, Renhe Town, Yubei District, Chongqing

• Tax NO.:

  91500000202851807X

• Registered Funds:

  196.54 million yuan

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