Acyclovir Injection

Acyclovir has an inhibitory effect on herpes simplex virus, varicella zoster virus, cytomegalovirus, etc. in vitro. The drug is easily taken up by herpes simplex virus, then phosphorylated into triphosphate, which inhibits viral replication in two ways: interfering with viral DNA polymerase and inhibiting viral replication; under the action of DNA polymerase, it binds to the growing DNA chain, causing the extension of the DNA chain to be interrupted.

Main ingredient: Acyclovir

Injectable

1. Herpes simplex virus infection: used for the treatment of primary and recurrent mucocutaneous infections in immunocompromised individuals and the prevention of recurrent cases; also used for the treatment of herpes simplex encephalitis. 2. Herpes zoster: used for the treatment of severe herpes zoster in immunocompromised individuals or disseminated herpes zoster in immunocompetent individuals. 3. Treatment of varicella in immunocompromised individuals.

Preparation of intravenous solution: This product is diluted with 0.9% saline or 5% glucose water to at least 100ml, so that the final drug concentration does not exceed 7g/L, otherwise it is easy to cause phlebitis. Intravenous drip: 1. Adults: (1) Initial treatment of severe genital herpes: 5mg/kg per body weight every 8 hours for 5 days. (2) Skin and mucous membrane herpes simplex or severe herpes zoster in immunocompromised patients: 5-10mg/kg per body weight every 8 hours, intravenous drip for more than 1 hour, for 7-10 days. (3) Herpes simplex encephalitis: 10mg/kg per body weight every 8 hours for 10 days. (4) Adults with acute or chronic renal insufficiency should not use this product intravenously, because too fast a drip rate may cause renal failure.

1 Common adverse reactions: If the injection concentration is too high (10g/L), it may cause phlebitis, and inflammation may occur at the injection site when overflow occurs. It may also cause skin itching or urticaria. 2 Rare adverse reactions: When administered by injection, especially intravenous injection, there may be acute renal insufficiency, hematuria and hypotension. 3 Rare adverse reactions: When administered by injection, central nervous system symptoms such as coma, confusion, hallucinations, and epilepsy may occur. 4 The following symptoms should be noted if they persist or are obvious: mild headache caused by injection (common), sweating (rare).

1. Fertility and pregnant women: Large doses of injection can cause testicular atrophy and sperm count reduction in animals. The drug can pass through the placenta, and animal experiments have confirmed that it has no effect on the embryo. 2. Breastfeeding mothers: The concentration of the drug in breast milk is 0.6 to 4.1 times the blood concentration, but no abnormalities have been found in infants.

1. When used intravenously with interferon or methotrexate (intrathecal), it may cause mental abnormalities and should be used with caution. 2. When used intravenously with nephrotoxic drugs, it may aggravate nephrotoxicity, especially in patients with renal insufficiency. 3. When used in combination with zidovudine, it may cause nephrotoxicity, manifested as deep lethargy and fatigue.

Keep away from light and store in a sealed container.

10ml:0.25g

Fuan Pharmaceutical Group Yantai Justaware Pharmaceutical Co., Ltd.

• Founded in:

  1990-09-17

• Address:

  No. 1, Yanfu Road, Zhifu District, Yantai City, Shandong Province

• Tax NO.:

  91370600165111227Y

• Registered Funds:

  240.1601 million yuan

• Website:

  Log in to view

• Email:

  Log in to view