Potassium Chloride Injection

Potassium is the main cation in cells, with a concentration of 150-160 mmol/L, while the main cation outside cells is sodium ions. The serum potassium concentration is only 3.5-5.0 mmol/L. The body mainly relies on Na+-K+ ATPase on the cell membrane to maintain the difference in K+ and Na+ concentration inside and outside cells. The acid-base balance in the body affects potassium metabolism. For example, in acidosis, H+ enters the cell to maintain the potential difference inside and outside the cell, and K+ is released outside the cell to cause or aggravate hyperkalemia. Metabolic disorders can also affect acid-base balance. The normal potassium ion concentration and concentration difference inside and outside the cell are closely related to certain functions of the cell, such as carbohydrate metabolism, glycogen storage and protein metabolism, nerve muscle (including the excitability and conductivity of the myocardium), etc.

The main ingredients of this product and their chemical names: Potassium chloride Molecular formula: KCl Molecular weight: 74.55

This product is a colorless clear liquid.

1. Treatment of hypokalemia caused by various reasons, such as insufficient food intake, vomiting, severe diarrhea, application of potassium-excreting diuretics, hypokalemic familial periodic paralysis, long-term use of glucocorticoids and hypokalemia caused by supplementation of hypertonic glucose, etc. 2. Prevention of hypokalemia. When the patient has potassium loss, especially if hypokalemia is harmful to the patient (such as patients using digitalis drugs), preventive potassium salt supplementation is required, such as eating very little, severe or chronic diarrhea, long-term use of adrenocortical hormones, potassium-losing nephropathy, Bartter syndrome, etc. 3. Digitalis poisoning causes frequent multifocal premature beats or rapid arrhythmias

For patients with severe hypokalemia or those who cannot take the medicine orally. General usage: Add 10-15 ml of 10% potassium chloride injection to 500 ml of 5% glucose injection and drip (avoid direct intravenous drip and push injection). The dose, concentration and speed of potassium supplementation are determined according to the clinical condition, blood potassium concentration and improvement of electrocardiogram potassium deficiency pattern. The potassium concentration should not exceed 3.4 g/L (45 mmol/L). The potassium supplementation speed should not exceed 0.75 g/hour (10 mmol/hour). The daily potassium supplementation amount is 3-4.5 g (40-60 mmol). Potassium deficiency in the body causes severe rapid ventricular ectopic In case of arrhythmia, such as torsade de pointes, short-term recurrent attacks, multiple ventricular tachycardia, ventricular flutter and other life-threatening serious arrhythmias, potassium salt concentration should be high (0.5% or even 1%), and the drip rate should be fast 1.5g/hour (20mmol/hour). The potassium supplementation amount can reach 10g or more per day. If the condition is critical, the potassium supplementation concentration and rate can exceed the above regulations, but the blood potassium and electrocardiogram should be closely monitored to prevent the occurrence of hyperkalemia. The pediatric dose is calculated based on 0.22g/kg (3mmol/kg) of body weight or 3g/m2 of body surface area per day.

1. When the intravenous infusion concentration is high and the speed is fast or the vein is thin, it is easy to stimulate the venous lining and cause pain. 2. When the infusion speed is fast or the original renal function is impaired, attention should be paid to the occurrence of hyperkalemia. Once hyperkalemia occurs, it should be treated urgently.

1. Hyperkalemia patients 2. Acute renal insufficiency and chronic renal insufficiency are contraindicated

Precautions for children: This experiment has not been conducted and there are no reliable references. Precautions for pregnancy and lactation: No special findings. Precautions for the elderly: The kidneys of the elderly have decreased K+ clearance function, and hyperkalemia is more likely to occur when potassium salts are used.

1. Adrenal glucocorticoids, especially those with more obvious mineralocorticoid effects. Adrenal mineralocorticoids and adrenocorticotropic hormone (ACTH) can promote urinary potassium excretion. When used in combination with this product, the efficacy of potassium salts is reduced. 2. Anticholinergic drugs can aggravate the gastrointestinal irritation of oral potassium salts, especially potassium chloride. 3. Non-steroidal anti-inflammatory analgesics aggravate the gastrointestinal reactions of oral potassium salts. 4. When used in combination with stored blood (30mmol/L of potassium for storage less than 10 days, 65mmol/L of potassium for storage more than 10 days), potassium-containing drugs and potassium-sparing diuretics, the chance of hyperkalemia increases, especially in patients with renal damage. 5. Angiotensin-converting enzyme inhibitors and cyclosporine A can inhibit aldosterone secretion and reduce urinary potassium excretion. Therefore, hyperkalemia is prone to occur when used in combination. 6. Heparin can inhibit the synthesis of aldosterone and reduce urinary potassium excretion. Hyperkalemia is prone to occur when used in combination. In addition, heparin can increase the chance of gastrointestinal bleeding.

Keep tightly closed.

10ml:1g

36 months

Shanghai Sine Jinzhu Pharmacy Co., Ltd.

• Founded in:

  1993-12-01

• Address:

  No. 6485, Tingwei Road, Jinshan District, Shanghai

• Tax NO.:

  913101161342488616

• Registered Funds:

  50 million yuan

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