Levofloxacin Hydrochloride Injection

This product is the levorotatory form of ofloxacin, and its antibacterial activity is about 2 times that of ofloxacin. Its main mechanism of action is to inhibit bacterial DNA gyrase activity and inhibit bacterial DNA replication. This product has the characteristics of a broad antibacterial spectrum and strong antibacterial effect. It has strong antibacterial activity against most Enterobacteriaceae, such as Klebsiella pneumoniae, Proteus, Salmonella typhi, Shigella, and some Escherichia coli. It also has good antibacterial effects on some Staphylococci, Streptococcus pneumoniae, Haemophilus influenzae, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Chlamydia, etc.

Levofloxacin hydrochloride. Chemical name: (S)-(-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-[1,4]benzoxazine-6-carboxylic acid hydrochloride monohydrate. Molecular formula: C18H20FN3O4HClH2O. Molecular weight: 415.85.

This product is a yellow-green clear liquid.

This product is used for the following infections caused by sensitive bacteria: 1. Sexually transmitted diseases: sexually transmitted diseases caused by chlamydia, mycoplasma, gonococcus, bacteria, etc. Such as chlamydial and mycoplasmal urethritis, vaginitis, gonorrhea, bacterial vaginitis, etc. 2. Urinary system infections: pyelonephritis, cystitis, prostatitis, epididymitis, etc. 3. Respiratory system infections: acute bronchitis, chronic bronchitis, bronchiectasis combined with infection, pneumonia, etc. 4. Skin and soft tissue infections: infectious herpes, cellulitis, lymphangiitis, subcutaneous abscesses, etc. 5. Intestinal infections: bacterial dysentery, infectious enteritis, salmonella enteritis, typhoid and paratyphoid. 6. Surgical infections: prevention and treatment of infections before, during and after surgery.

Intravenous drip. For adults, take 0.2 g each time, add 100 ml of 5% glucose solution or 0.9% sodium chloride solution to dilute, and the drip rate should be at least 60 minutes for every 100 ml, twice a day. For patients with severe infection and those whose pathogens are less sensitive to this product (such as Pseudomonas aeruginosa), the maximum daily dose can be increased to 0.6 g, divided into 2 intravenous drips.

During medication, symptoms such as nausea, vomiting, abdominal discomfort, diarrhea, loss of appetite, abdominal pain, abdominal distension, insomnia, dizziness, headache and other neurological symptoms, as well as rash and itching may occur. Transient liver function abnormalities may also occur, such as increased serum transaminase and increased serum total bilirubin. The incidence of the above adverse reactions is between 0.1% and 5%, and occasionally increased blood urea nitrogen, fatigue, fever, palpitations, abnormal taste, etc. are seen. Generally, they are well tolerated and disappear quickly after the end of the course of treatment.

It is contraindicated for patients who are allergic to quinolones.

Precautions for children: Patients under 18 years old are prohibited from using this drug. Precautions for pregnancy and lactation: Precautions for pregnant and lactating women are prohibited. Precautions for the elderly: This drug is mainly excreted through the kidneys (see "Pharmacokinetics"). Since most elderly patients have low renal function, they may have persistently high blood drug concentrations. Therefore, attention should be paid to the dosage and administration should be cautious.

When this product is used simultaneously with magnesium or aluminum-containing antacids, sucralfate, metal cations (such as iron), zinc-containing multivitamin preparations, etc., it will interfere with the absorption of this product by the gastrointestinal tract, causing the concentration of this drug in various systems to be significantly reduced. Therefore, the time of taking the above-mentioned drugs should be at least 2 hours before or after using this product to avoid using it simultaneously with theophylline. If it is necessary to use it simultaneously, the blood concentration of theophylline should be monitored and the dosage should be adjusted accordingly. When used simultaneously with warfarin or its derivatives, the prothrombin time or other coagulation tests should be monitored. When used simultaneously with non-steroidal anti-inflammatory drugs, there is a possibility of causing convulsions. When used simultaneously with oral hypoglycemic drugs, it may cause blood sugar disorders, including hyperglycemia and hypoglycemia. Therefore, attention should be paid to monitoring blood sugar concentration during medication. Once hypoglycemia occurs, this product should be discontinued immediately and appropriate treatment should be given.

Keep away from light and store in airtight container.

2ml:0.2g (calculated according to C18H20FN3O4)

24 months

Huarun Shuanghe Limin Pharmaceutical (Ji'nan) Co., Ltd.

• Founded in:

  2001-06-28

• Address:

  No. 1, Limin Road, Mingshui Street, Zhangqiu District, Jinan City, Shandong Province

• Tax NO.:

  91370181163446867C

• Registered Funds:

  23.85 million yuan

• Email:

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