Progesterone

Progesterone is a natural progestogen secreted by the corpus luteum of the ovary. It has a significant morphological effect on the endometrium stimulated by estrogen in the body and is necessary to maintain pregnancy. 1. In the late menstrual cycle, it causes the glands in the uterine mucosa to grow, the uterus to become congested, and the endometrium to thicken, preparing for the implantation of the fertilized egg. After the fertilized egg is implanted, it causes the placenta to form, reduces the excitability of the pregnant uterus, inhibits its activity, and allows the fetus to grow safely. 2. Under the combined action of estrogen, it promotes full breast development in preparation for milk production. 3. It closes the cervical opening, reduces and thickens the mucus, making it difficult for sperm to penetrate; in large doses, it inhibits the secretion of pituitary gonadotropin through negative feedback on the hypothalamus, producing an inhibitory effect on ovulation. This product reaches its peak blood concentration after 1 to 3 hours of oral administration. It is inactivated due to rapid metabolism, so it is generally administered by injection, but sublingual or vaginal or rectal administration is also effective. 4. It is rapidly absorbed through the vaginal mucosa, and the blood concentration reaches its peak after 2 to 6 hours. It is mainly used clinically for habitual abortion, dysmenorrhea, excessive menstrual bleeding or metrorrhagia, amenorrhea, etc. Oral administration of large doses is also used for diseases caused by progesterone deficiency, such as premenstrual syndrome, menstrual disorders caused by cessation of ovulation, benign breast disease, premenopause and menopause, etc. Vaginal administration can replace oral administration, especially for patients with liver disease.

Progesterone

It mainly promotes and maintains uterine changes in the early stages of pregnancy and is used to treat habitual abortion, threatened abortion, irregular menstruation, etc.

Intramuscular injection, 10-20 mg per time. Oral or vaginal administration: 100 mg per time, once in the morning and once in the evening (2 hours before bedtime), for 10 consecutive days per cycle (usually on the 17th to 26th day of the cycle).

Breakthrough bleeding, vaginal spotting, weight gain or loss, changes in the cervical squamous-columnar junction, changes in cervical secretions, breast swelling, nausea, dizziness, headache, fatigue, fever, insomnia, allergies with or without itching, melasma, chloasma, obstructive jaundice, abnormal liver function.

Jiangsu Jiaerke Pharmaceuticals Group Corp., Ltd.

• Founded in:

  1993-06-08

• Address:

  No. 302, Huzhuangtou, Sanhuangmiao Village Committee, Zhenglu Town, Tianning District

• Tax NO.:

  9132040225099911X1

• Registered Funds:

  60 million yuan

• Website:

  Log in to view

• Email:

  Log in to view