Flunarizine Hydrochloride Capsules
Function and Efficacy
This product is a selective blocker of calcium entering cells. It can reduce venous contraction and prevent excessive calcium ions from entering cells across the membrane under various stimulations and causing cell damage. This product has the following effects: 1. Inhibit vasoconstriction, and has a lasting inhibitory effect on persistent vasoconstriction caused by vasoconstrictor substances, especially on the basilar artery and internal carotid artery, and its effect is 15 times stronger than that of cerbrine; 2. Vestibular inhibition, which can increase blood flow in the cochlear radiating arterioles and improve vestibular organ circulation; 3. Anti-epileptic effect, this product can block calcium overload and prevent paroxysmal depolarization, cell discharge, and thus avoid epileptic seizures; 4. Protect the myocardium and significantly reduce ischemic myocardial damage; 5. Flunarizine also has the function of improving renal function and can be used for chronic renal failure; in addition, this product also has anti-histamine effect.
Ingredients
The main ingredient of this product is flunarizine hydrochloride.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Flunarizine dihydrochlorideIngredients |
This product is a selective blocker of calcium entering cells, which can reduce venous contraction and prevent excessive calcium ions from entering cells across the membrane under various stimulations and causing cell damage; 1. Inhibit vasoconstriction, and have a lasting inhibitory effect on persistent vasoconstriction caused by vasoconstrictor substances, especially on the basilar artery and internal carotid artery, and its effect is 15 times stronger than that of cephalosporin; 2. Vestibular inhibitory effect, which can increase the blood flow of cochlear radiating arterioles and improve vestibular organ circulation; 3. Anti-epileptic effect, this product can block calcium overload and prevent paroxysmal depolarization, cell discharge, and thus avoid epileptic seizures; 4. Protect the myocardium and significantly reduce ischemic myocardial damage; 5. Flunarizine also has the function of improving renal function and can be used for chronic renal failure; in addition, this product also has anti-histamine effect. More |
30484-77-6 | 25 |
Appearance
This product is in the form of capsules.
Indication
1. Insufficient blood supply to the brain, vertebral artery ischemia, cerebral thrombosis, etc. 2. Tinnitus, dizziness. 3. Prevention of migraine. 4. Auxiliary treatment of epilepsy.
Usage and Dosage
1. For central vertigo and peripheral vertigo, including vertebrobasilar artery insufficiency, use flunarizine 10-20 mg per day, 2-8 weeks as a course of treatment. 2. For idiopathic tinnitus, use flunarizine 10 mg once a night, 10 days as a course of treatment. 3. For intermittent claudication, use flunarizine 10-20 mg per day. 4. For migraine prevention, use flunarizine 5-10 mg twice a day. 5. For cerebral arteriosclerosis and recovery period of cerebral infarction, use flunarizine 5-10 mg per day.
Adverse Reactions
1. Adverse reactions of the central nervous system include: drowsiness and fatigue are the most common. Depression may occur in long-term users, which is more common in female patients. Extrapyramidal symptoms include bradykinesia, akathisia, mandibular dyskinesia, tremor, rigidity, etc. Most of them appear after 3 weeks of medication and disappear after stopping the medication. It is more likely to occur in the elderly. A small number of patients may experience insomnia, anxiety and other symptoms. 2. Gastrointestinal symptoms include: burning sensation in the stomach, hyperappetite, increased food intake, and weight gain. 3. Others: A small number of patients may experience rash, dry mouth, galactorrhea, muscle aches and other symptoms. Most of these symptoms are transient.
Precautions
This drug is contraindicated if you have a history of allergy to it or a history of depression, and it is contraindicated in patients with acute cerebral hemorrhagic disease.
Special Population Medication
Precautions for children: Since this drug can pass through the blood-brain barrier, it has clear adverse reactions in the central nervous system, and the central nervous system of children is sensitive to drugs, and the metabolic function is relatively weak. Although there is no detailed research data on the use of drugs in children, in principle, children should be cautious or avoid using this drug. Precautions for pregnancy and lactation: Since this drug can pass through the placental barrier and can be secreted with breast milk, although there are no reports of teratogenicity and effects on embryonic development, in principle, pregnant women and lactating women should not use this drug. Precautions for the elderly: Since the nervous system of elderly patients is also more sensitive and their metabolic capacity is weaker, the dosage should be used with caution as appropriate.
Drug Interactions
1. When used in combination with alcohol, hypnotics or sedatives, the sedative effect is aggravated. 2. When used in combination with phenytoin sodium and carbamazepine, the blood concentration of flunarizine can be reduced. 3. When used in combination with flunarizine in patients undergoing radiotherapy, the killing power of tumor cells can be increased. 4. Adding flunarizine to anti-epileptic drug treatment can improve the anti-epileptic effect.
Storage
Keep away from light and store in sealed container.
Packaging Specification
5mg (based on C26H26F2N2)
Validity Period
36 months
Manufacturer
Shanghai Xudong Haipu Pharmaceutical Co., Ltd.
-
Founded in:
1993-01-06 -
Address:
No. 879, Jinhu Road, China (Shanghai) Pilot Free Trade Zone -
Tax NO.:
91310115607203592Y -
Registered Funds:
$9,478,623 -
Website:
-
Email: