Rifampicin eye drops

Rifampicin is a semi-intact broad-spectrum fungicide that firmly binds to the beta subunit of DNA-dependent polymerase, inhibiting the synthesis of bacterial RNA and preventing the enzyme from connecting to DNA, thereby blocking the RNA transcription process.

Rifampin.

The pills of this product are dark red, and the buffer solution is a colorless clear solution.

Treat trachoma and eye infections caused by sensitive bacteria.

Eye drops: 1-2 drops at a time, 4-6 times a day.

Cold, difficulty breathing, dizziness, fever, headache, orange-red or reddish-brown tears, etc. In addition, it can also cause skin redness or rash (allergic reaction), itching and other symptoms.

1. Patients who are allergic to this product are prohibited from using it. 2. Patients with severe liver dysfunction are prohibited from using it. 3. Patients with biliary obstruction are prohibited from using it. 4. Pregnant women are prohibited from using it. Elderly people and children should use it with caution.

Precautions for children: Since no research has been conducted on the use of this product in children under 5 years old, children under 5 years old should use it with caution. Precautions for pregnancy and lactation: Pregnant women are prohibited to use it. Precautions for the elderly: Patients aged 5 years should use it with caution due to decreased liver function.

1. Drinking alcohol daily while taking rifampicin can increase the incidence of rifampicin hepatotoxicity and increase the metabolism of rifampicin. The rifampicin dose needs to be adjusted and the patient should be closely monitored for signs of hepatotoxicity. 2. When adrenocortical hormones (glucocorticoids, mineralocorticoids), anticoagulants, coumarin or indanedione derivatives, oral hypoglycemic drugs, corticotropin, dapsone, digitalis glycosides, disopyramide, quinidine, etc. are used in combination with rifampicin, the latter can stimulate the activity of liver microsomal enzymes, which can reduce the efficacy of the above drugs. Therefore, except for digoxin and dapsone, the above drugs need to be adjusted in dose before and during rifampicin. When this product is used in combination with coumarins or indanediones, the prothrombin time should be measured daily or regularly to adjust the dose accordingly. 3. Para-aminosalicylate can affect the absorption of rifampicin, resulting in a decrease in the blood concentration of rifampicin; when patients take para-aminosalicylate and rifampicin, the two drugs should be separated by at least 6 hours. 4 Rifampicin can stimulate the metabolism of estrogen or reduce its enterohepatic circulation, reduce the effect of oral contraceptives, lead to irregular menstruation, intermenstrual bleeding and unplanned pregnancy. When patients take rifampicin, they should switch to other contraceptive methods. 5 Rifampicin can induce liver microsomal enzymes, increase the metabolism of anti-tumor drugs dacarbazine and cyclophosphamide, the formation of alkylated metabolites, and promote the decrease of white blood cells, so the dose needs to be adjusted. 6 The combination of isoniazid with rifampicin or miconazole (intravenous) and ketoconazole can increase the risk of hepatotoxicity, especially in patients with existing liver damage and isoniazid fast acetylation. In addition, the combination of isoniazid or rifampicin with miconazole or ketoconazole can reduce the blood concentration of the latter two, so this product and isoniazid should not be used in combination with imidazoles. 7 The combination of rifampicin and diazepam (diazepam) can increase the elimination of the latter and reduce its blood concentration, so the dose needs to be adjusted. 8 Rifampicin combined with ethionamide can aggravate its adverse reactions. 9 Rifampicin can increase the degradation of levothyroxine in the liver, so the dose of levothyroxine should be increased when the two are used together. Rifampicin can also increase the metabolism of methadone and mexiletine in the liver, causing methadone withdrawal symptoms and reduced mexiletine blood concentrations, so the latter two need to adjust the dose when used together. Rifampicin can increase the metabolism of phenytoin sodium in the liver, so the blood concentration of phenytoin sodium should be measured and the dosage should be adjusted when the two are used together. 10 Probenecid can compete with rifampicin for uptake by liver cells, increase the blood concentration of rifampicin and produce toxic reactions. However, this effect is unstable, so it is usually not advisable to add disulfide to increase the blood concentration of rifampicin. 11 Rifampicin can increase the elimination of trimethoprim, increase the metabolism of xanthines, and increase the clearance of theophylline. Combination with ethambutol may enhance visual impairment. It has an enzymatic effect, which can accelerate the metabolism of dicoumarol anticoagulants, oral hypoglycemic drugs, digitalis, corticosteroids, dapsone and other drugs and reduce their efficacy. Long-term use of this product can reduce the effect of contraceptives and lead to contraceptive failure. This product can interfere with the metabolism of vitamin D and cause osteomalacia. The risk of disease is greater in malnourished people or pregnant women.

Keep tightly closed in a cool, dark and dry place.

Each tablet contains 5 mg of rifampicin and 10 ml of buffer solution

24 months

Anhui Aike'er Pharmaceutical Co., Ltd.

• Founded in:

  2014-06-20

• Address:

  No. 290, Guandian Economic Development Zone, Mingguang City, Anhui Province

• Tax NO.:

  913411823976695617

• Registered Funds:

  10 million yuan

• Email:

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