Cloxacillin Sodium for Injection

This product is a semi-synthetic penicillin, which is acid-resistant and penicillinase-resistant. It has antibacterial activity against Gram-positive cocci and Neisseria. Its antibacterial activity against enzyme-producing strains of Staphylococcus (including Staphylococcus aureus and coagulase-negative Staphylococci) is stronger than that of oxacillin, but its antibacterial effect against penicillin-sensitive Staphylococci and various streptococci is weaker than that of penicillin, and it is ineffective against methicillin-resistant Staphylococci.

Cloxacillin Sodium

This product is white powder or crystalline powder

This product is only suitable for the treatment of penicillinase-producing staphylococcal infections, including sepsis, endocarditis, pneumonia, and skin and soft tissue infections, etc. It can also be used for mixed infections caused by pyogenic Streptococcus or pneumococcus and penicillin-resistant staphylococci.

1 Intramuscular injection: 2g per day for adults, divided into 4 times; 25-50mg/kg per day for children, divided into 4 times. 0.5% lidocaine can be added during intramuscular injection to reduce local pain. 2 Intravenous drip: 4-6g per day for adults, divided into 2-4 times; 50-10mg/kg per day for children, divided into 2-4 times. 3 For newborns weighing less than 2kg, 25mg/kg per day is given according to body weight every 12 hours when they are 1-14 days old, and 25mg/kg per day is given according to body weight every 8 hours when they are 15-30 days old; for those weighing more than 2kg, 25mg/kg per day is given according to body weight every 8 hours when they are 1-14 days old, and 25mg/kg per day is given according to body weight every 6 hours when they are 15-30 days old.

1 Allergic reactions: Various types of rashes such as urticaria are the most common, leukopenia, interstitial nephritis, asthma attacks and serum sickness reactions may also occur. Severe cases such as anaphylactic shock are occasionally seen; once anaphylactic shock occurs, it is necessary to rescue on the spot, keep the airway open, inhale oxygen, and give treatment measures such as epinephrine and glucocorticoids. 2 Intravenous injection of this product may occasionally cause nausea, vomiting and elevated serum aminotransferase. 3 Large doses of this product may cause convulsions and other central nervous system toxic reactions. 4 There have been reports of infants developing hematuria, proteinuria and uremia after using large doses of this product. 5 Agranulocytosis or cholestatic jaundice occurred in individual cases. Occasionally

It is contraindicated in patients with a history of allergy to penicillins or a positive penicillin skin test.

1. This product is incompatible with aminoglycosides, norepinephrine, metaraminol, phenobarbital, vitamin B group, vitamin C and other drugs, and should not be dripped in the same bottle. 2. Probenecid can reduce the renal tubular secretion of cloxacillin and prolong the serum half-life of this product. 3. Aspirin and sulfonamides inhibit the binding of this product to serum proteins and increase the free blood concentration of this product.

Sealed, store in a dry place.

1.5g (calculated as C19H18ClN3O5S)

Hainan General Sanyang Pharmaceutical Co., Ltd.

• Founded in:

  2001-08-20

• Address:

  No. 8 Haili Road, Xiuying District, Haikou City

• Tax NO.:

  91460000730051264Q

• Registered Funds:

  100 million yuan

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