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Sodium cloxacillin monohydrate

Sodium cloxacillin monohydrate structure

CAS No:
7081-44-9
Formula:
C19H18ClN3O5S.H2O.Na
Chemical Name:
Sodium cloxacillin monohydrate
Synonyms:
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,sodium salt,hydrate (1:1:1),(2S,5R,6R)-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-,monosodium salt,monohydrate;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt,monohydrate,[2S-(2α,5α,6β)]-;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt,monohydrate,(2S,5R,6R)-;3-(o-Chlorophenyl)-5-methyl-4-isoxazolyl penicillin sodium salt monohydrate;Sodium 6-[3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydrate;Sodium cloxacillin monohydrate;Cloxacillin sodium hydrate
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Cloxacillin sodium monohydrate is a semi-synthetic antibiotic that is a chlorinated derivative of oxacillin.Target: AntibacterialCloxacillin sodium (Cloxacap) is a sodium salt of cloxacillin that is a penicillinase-resistant, acid resistant, semi-synthetic penicillin. Cloxacillin sodium exerts a bactericidal action against susceptible microorganisms during the stage of active multiplication. Cloxacillin sodium acts through the inhibition of biosynthesis of cell wall mucopeptides. Cloxaci

A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.

Sodium cloxacillin monohydrate Basic Attributes

Molecular Weight：

475.88

Exact Mass：

475.058

EC Number：

211-390-9

DSSTox ID：

DTXSID4045551

HScode：

2941109900

Characteristics

PSA：

142

XLogP3：

0.99210

Melting Point：

170 °C (decomp)

Boiling Point：

689℃

Flash Point：

>110°(230°F)

Water Solubility：

H2O: soluble 50mg/mL

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38-42/43

safety instructions：

26-36

RTECS Number：

XH8920000

Marks：

Precautionary statement(s)：

P261-P280-P284-P304 + P340-P305 + P351 + P338-P342 + P311

Hazard Statements：

H315-H317-H319-H334-H335

GHS Classification：

|Danger|H302 (11.11%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P272, P280, P285, P301+P312, P302+P352, P304+P341, P305+P351+P338, P321, P330, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, and P501|Aggregated GHS information provided by 9 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

Chloroxacillin

Sodium cloxacillin monohydrate Use and Manufacturing

Methods of Manufacturing

O-toluidine undergoes operations such as diazotization, replacement, chlorination, hydrolysis, and oximation. Obtain o-chlorobenzoxime chloride, then cyclize with ethyl acetoacetate, chlorinate with phosphorus pentachloride to obtain 3-o-chlorophenyl-5-methyl-4isoxanoyl chloride, and finally condense with 6-APA O-cloxacillin base, sodium isooctate plus salt, that is o-cloxacillin sodium.

Uses

antibacterial

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:476.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:476.0659035
Monoisotopic Mass:476.0659035
Topological Polar Surface Area:139
Heavy Atom Count:31
Complexity:722
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Material

o-Toluidine

Drug Function and Efficacy

Acid-resistant and enzyme-resistant semi-synthetic penicillin has a broad-spectrum killing effect on Gram-positive and Gram-negative bacteria and is effective against penicillin-resistant Staphylococcus aureus.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ampicillin Sodium and Cloxacillin Sodium for Injection
Ingredients	This product is a compound preparation, its components are ampicillin sodium and cloxacillin sodium.
Indication	1 This product is incompatible with aminoglycosides, norepinephrine, metaraminol, phenobarbital, B vitamins, vitamin C and other drugs, and should not be dripped in the same bottle. 2 Probenecid can reduce the renal tubular secretion of cloxacillin and prolong the serum half-life of this product. 3 Aspirin and sulfonamides inhibit the binding of this product to serum proteins and increase the free blood concentration of this product. 4 Ampicillin and kanamycin have synergistic antibacterial effects on Escherichia coli and Proteus. 5 This product should be dripped alone and should not be dripped in the same bottle with the following drugs: aminoglycosides, clindamycin phosphate, lincomycin hydrochloride, polymyxin B, succinylcholine,
Specifications	0.5g
Manufacturer	Shanxi Shuangyan Pharmaceutical Co., Ltd.

Ampicillin and Cloxacillin Sodium Capsules
Indication	1. Probenecid can reduce the renal tubular secretion of cloxacillin and prolong the serum half-life of this product. 2. Aspirin and sulfonamides inhibit the binding of this product to serum proteins and increase the free blood concentration of this product. 3. Ampicillin and kanamycin have synergistic antibacterial effects on Escherichia coli and Proteus. 4. Allopurinol can increase the incidence of ampicillin rash reactions, especially in hyperuricemia. 5. Ampicillin can stimulate estrogen metabolism or reduce its enterohepatic circulation, thereby reducing the effectiveness of oral contraceptives.
Specifications	0.5g (ampicillin 0.25g and cloxacillin 0.25g)

Ampicillin and Cloxacillin Sodium Capsules

Indication

1. Probenecid can reduce the renal tubular secretion of cloxacillin and prolong the serum half-life of this product. 2. Aspirin and sulfonamides inhibit the binding of this product to serum proteins and increase the free blood concentration of this product. 3. Ampicillin and kanamycin have synergistic antibacterial effects on Escherichia coli and Proteus. 4. Allopurinol can increase the incidence of ampicillin rash reactions, especially in hyperuricemia. 5. Ampicillin can stimulate estrogen metabolism or reduce its enterohepatic circulation, thereby reducing the effectiveness of oral contraceptives.

Specifications

0.5g (ampicillin 0.25g and cloxacillin 0.25g)

Cloxacillin Sodium for Injection
Ingredients	Cloxacillin Sodium
Indication	1. This product is incompatible with aminoglycosides, norepinephrine, metaraminol, phenobarbital, vitamin B group, vitamin C and other drugs, and should not be dripped in the same bottle. 2. Probenecid can reduce the renal tubular secretion of cloxacillin and prolong the serum half-life of this product. 3. Aspirin and sulfonamides inhibit the binding of this product to serum proteins and increase the free blood concentration of this product.
Specifications	Calculated as C19H18ClN3O5S 1.5g
Manufacturer	Shanghai SPH New ASIA Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

FRESENIUS KABI IPSUM SRL

United States
Active
Reyoung Pharmaceutical Co., Ltd.

China
Active
CSPC Zhongnuo PHARMACEUTICAL(Shijiazhuang) Co., Ltd.

China
Active

See More Registered Holders

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Cloxacillin sodium hydrate CAS 7081-44-9

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Content: 99%

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Guide of Sodium cloxacillin monohydrate

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Material
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

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