Nimesulide Capsules

This product is a non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic and antipyretic effects. Its mechanism of action is not yet fully understood, but it may be mainly related to the inhibition of prostaglandin synthesis, mediator release of leukocytes and oxidative reactions of polymorphonuclear leukocytes.

The main ingredient of this product is nimesulide, and its chemical name is: N-[4-nitro-2-phenoxyphenyl] methanesulfonamide.

This product is a capsule, and the contents are light yellow powder.

This product is a non-steroidal anti-inflammatory drug with analgesic, anti-inflammatory and antipyretic effects. Its mechanism of action is not yet fully understood, but it may be mainly related to the inhibition of prostaglandin synthesis, mediator release of leukocytes and oxidative reactions of polymorphonuclear leukocytes.

Oral administration: 0.05-0.1g at a time, twice a day, after meals. The maximum single dose should not exceed 100mg, and the course of treatment should not exceed 15 days. It is recommended to use the minimum effective dose and the shortest course of treatment to reduce the occurrence of adverse drug reactions.

This product has fewer side effects. Common side effects are heartburn, stomach pain and gastrointestinal disorders, but the symptoms are mild and short-lived, and rarely require interruption of treatment. In rare cases, patients develop allergic rashes after taking it. Even if the above symptoms do not occur when using nimesulide, it should be noted that this product, like other non-steroidal anti-inflammatory drugs, may cause dizziness, drowsiness, gastric ulcers or gastrointestinal bleeding and Stevens-Johnson syndrome.

1. Patients who are allergic to this product, acetylsalicylic acid or other non-steroidal drugs are contraindicated. 2. Patients with active gastrointestinal bleeding or active peptic ulcer are contraindicated. 3. Patients with severe liver dysfunction and severe renal dysfunction (creatinine clearance rate 30 ml/min) are contraindicated.

Precautions for children: Children under 12 years old are prohibited from using. Precautions for pregnancy and lactation: No test has been conducted to confirm whether nimesulide is toxic to the fetus, and it is not recommended for pregnant women. It has not been confirmed whether nimesulide is excreted through breast milk, and it is not recommended for lactating women. Precautions for the elderly: Due to the decline in renal function in elderly patients, the dosage should be strictly followed by the doctor's instructions, and the doctor may reduce it appropriately according to the situation.

Due to the high plasma protein binding rate of this product, it may displace other protein-bound drugs. Furosemide affects the absorption of nimesulide, causing the AUC value of nimesulide to decrease by about 25%; fenofibrate, tolbutamide, and salicylic acid can displace nimesulide from plasma proteins, while furosemide, glibenclamide, and therapeutic doses of warfarin have no effect on the binding rate of nimesulide to proteins.

Seal and store in a dry place. The validity period is tentatively one year.

0.1g

24 months

Shanxi Shuangyan Pharmaceutical Co., Ltd.

• Founded in:

  2004-06-18

• Address:

  Datong Development Zone Pharmaceutical Industrial Park

• Tax NO.:

  91140200762481795D

• Registered Funds:

  250 million yuan

• Website:

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