Trimebutine Maleate Tablets

1 Gastric motility regulation effect: Adding 10-5g/ml of this product to the isolated guinea pig gastric vestibular circular muscle specimen can reduce the amplitude of its spontaneous movement. In addition, it can also increase the frequency and amplitude of the irregular weak movement of the same specimen at 28°C, making it tend to regular rhythmic contraction. When 3mg/kg of this product is intravenously injected into anesthetized dogs with cut thoracic vagus nerves, the irregular movement of the stomach can be regularized. For patients with digestive system diseases, intravenous injection of 1mg/kg of this product can inhibit the movement of hyperkinetic muscle groups, and at the same time, it can also be found that it can enhance the movement of hypokinetic muscle groups; 2. Inducing effect on propulsive movement of the digestive system After 4-6mg/kg of the drug was administered in the human jejunum, it was found that it can induce physiological propulsive movement of the digestive system in adults; 3. Improvement of gastric emptying function For patients with chronic gastritis who often have unexplained upper abdominal digestive tract discomfort, oral administration of 200mg of this product can improve the weakening of gastric emptying function, and at the same time, it can also inhibit hyperactivity of gastric emptying function; 4. Intestinal movement regulation In the experiment of isolated guinea pig colon specimens, at 10-5g/ml, it has the effect of increasing tension for low muscle tension (under low load), and reducing tension and amplitude for hypermuscular tension (under high load). Hyperkinesis of the large intestine caused by psychological fatigue load in allergic enteritis syndrome can be inhibited by taking 300mg of this product. For patients with hypermotility caused by neostigmine load, 50 mg intravenous administration can inhibit the movement of the ileum, ascending colon, and sigmoid colon to the pre-load level. 5. Regulatory effect on lower esophageal sphincter pressure (LESP) Experiments on lower esophageal sphincter pressure in anesthetized dogs showed that 0.6 mg/kg intravenous administration can reduce the increase in internal pressure caused by tetragastrin load, and can also restore the decrease in internal pressure caused by secretin; 6. Direct effect on digestive tract smooth muscle Experiments on isolated guinea pig gastric vestibule circular muscle specimens found that even in the presence of atropine, phentolamine, propranolol, and tetrodotoxin, this product still has a direct effect on digestive tract smooth muscle. Experiments on isolated guinea pig ileum found that this product can non-competitively inhibit the contraction caused by acetylcholine. It was also found that after the vagus nerve in the chest of anesthetized dogs was removed, it still had a direct effect on the gastrointestinal motility; 7 The peripheral antiemetic effect of the experiment on dogs found that although the inhibitory effect on apomorphine-induced vomiting was weak, for vomiting induced by copper sulfate, after intravenous injection of 3mg/kg or oral administration of 60mg/kg of this product, it can significantly prolong the time required to induce vomiting.

The main ingredient of this product is trimebutine maleate, whose chemical name is ()-3,4,5-trimethoxybenzoic acid (2-dimethylamino-2-phenyl) butyl maleate

This product is a white film-coated tablet.

Improvement of symptoms such as loss of appetite, nausea, vomiting, belching, abdominal distension, borborygmus, abdominal pain, diarrhea, constipation, etc. caused by gastrointestinal motility disorders. Irritable bowel syndrome.

For adults, take orally, 0.1-0.2 g each time, 3 times a day. The dosage can be appropriately increased or decreased according to age and symptoms, or as directed by a doctor.

Occasionally, there may be thirst, numbness in the mouth, abdominal borborygmi, abdominal distension, constipation, tachycardia, drowsiness, dizziness, headache, rash, increased aspartate aminotransferase (GOT) and alanine aminotransferase (GPT), etc., with an incidence of about 0.4%.

It is contraindicated in patients allergic to trimebutine maleate.

Precautions for children: Safety issues have not been established, so use with caution when necessary. Precautions for pregnancy and lactation: Safety issues have not been established, so use with caution when necessary. Precautions for the elderly: Elderly people usually have weaker physiological functions, so they need to pay attention to reducing the dosage.

Not yet clear.

Store tightly closed in a dry place at room temperature.

0.1g

Tentative 24 months

Shanxi Shuangyan Pharmaceutical Co., Ltd.

• Founded in:

  2004-06-18

• Address:

  Datong Development Zone Pharmaceutical Industrial Park

• Tax NO.:

  91140200762481795D

• Registered Funds:

  250 million yuan

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