Propiverine Hydrochloride Tablets
Function and Efficacy
1. Inhibition of bladder micturition movement in vivo (1) Increased bladder capacity Cystometritis showed that this drug could increase the maximum bladder capacity of anesthetized rats and dogs, as well as the maximum bladder capacity and effective bladder capacity of debulked dogs, but no significant increase in residual urine volume was observed. (2) Inhibition of micturition movement This drug could reduce the number of rhythmic contractions (micturition movement) during bladder filling in anesthetized rats and dogs. (3) Inhibition of bladder contraction induced by electrical stimulation This drug could reduce the contraction force of the bladder induced by electrical stimulation of the pelvic nerve in dogs, regardless of whether the pelvic nerve was cut off. 2. Effect on isolated bladder This drug could inhibit the contraction of bladder smooth muscle induced by acetylcholine, calcium chloride (rats, dogs, guinea pigs), and electrical stimulation (rats, dogs, rabbits) in a dose-related manner. 3. Mechanism of action This drug could inhibit the contraction of acetylcholine and calcium chloride on isolated bladder, have affinity for myosin receptors, and could inhibit the contraction induced by electrical stimulation that could not be inhibited by atropine. It could also inhibit the bladder contraction induced by stimulation of the cut pelvic nerve endings, indicating that this drug could directly act on bladder smooth muscle. In addition, the main metabolite of this drug, 1-methyl-4-piperidinyl-diphenylpropoxyacetic acid-N-oxide (N-oxide of this drug, hereinafter referred to as M-1) directly acts on smooth muscle, and 1-methyl-4-piperidinyl-benzoic acid-N-oxide (depropylated derivative of M-1, hereinafter referred to as M-2) has an anticholinergic effect. Therefore, this drug can directly act on smooth muscle and has an anticholinergic effect, but it is mainly because it directly inhibits smooth muscle and inhibits urination movement.
Ingredients
The main ingredient of this product is propiverine hydrochloride.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Propiverine hydrochlorideIngredients |
1. Inhibitory effect on urinary bladder in vivo: (1) Increase bladder capacity, increase the maximum bladder capacity of anesthetized rats and dogs, and the maximum bladder capacity and effective bladder capacity of decapitated dogs; (2) Inhibit urinary movement, reduce the number of rhythmic contractions during bladder filling in anesthetized rats and dogs; (3) Inhibit bladder contraction caused by electrical stimulation, reduce the bladder contraction force caused by electrical stimulation of the dog pelvic nerve regardless of whether the pelvic nerve is cut. 2. Effect on isolated bladder: It can inhibit the contraction of bladder smooth muscle caused by acetylcholine, calcium chloride, and electrical stimulation in a dose-related manner. 3. Mechanism of action: It can directly act on bladder smooth muscle and have anticholinergic effects, but it mainly inhibits urinary movement because it directly inhibits smooth muscle. More |
54556-98-8 | 4 |
Appearance
This product is white tablets.
Indication
Frequent urination and urinary incontinence caused by the following diseases or conditions: neurogenic bladder, neurogenic urinary incontinence, unstable bladder, irritative bladder conditions (chronic cystitis, chronic prostatitis).
Usage and Dosage
Oral administration: Adults generally take 20 mg (2 tablets) once a day after meals.
Adverse Reactions
Not yet clear.
Precautions
This product is contraindicated in the following cases: 1. Patients with pyloric, duodenal and intestinal occlusion (inhibits gastrointestinal smooth muscle contraction and peristalsis, which may aggravate symptoms). 2. Patients with lower urinary tract occlusion (relaxes detrusor muscle, aggravates symptoms). 3. Patients with glaucoma (anticholinergic effect increases intraocular pressure, aggravates symptoms). 4. Patients with severe heart disease (literature reports that this drug can cause extrasystoles of the heart, aggravating symptoms). 5. Patients who are allergic to this product.
Special Population Medication
Precautions for children: The effectiveness and safety of this product for children have not been established, and clinical use is not recommended. Precautions for pregnancy and lactation: The effectiveness and safety of this product for pregnant women have not been established; animal experiments have shown that this product can be detected in breast milk, and lactating women should stop breastfeeding when using it. Precautions for the elderly: Elderly patients often have impaired liver and kidney function. For safety reasons, they should start with 10 mg/day.
Drug Interactions
This product should not be used in combination with the following drugs: anticholinergics, tricyclic depressants, phenothiazines, monoamine oxidase inhibitors (may enhance anticholinergic effects).
Storage
seal.
Packaging Specification
10mg
Validity Period
24 months
Manufacturer
Shijiazhuang Huaxin Pharmaceutical Co., Ltd.
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Founded in:
1999-10-17 -
Address:
Nanhuan East Road, Lingshou County (Chengdong Industrial Park) -
Tax NO.:
9113012610458942X4 -
Registered Funds:
16 million yuan -
Website:
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Email: