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Penciclovir cream

Function and Efficacy

This product is a nucleoside antiviral drug, which has an inhibitory effect on type I and type II herpes simplex viruses in vitro. In virus-infected cells, viral thymidine deoxynucleoside kinase phosphorylates this product into penciclovir monophosphate, and then cellular kinase converts penciclovir monophosphate into penciclovir triphosphate. In vitro experiments have shown that penciclovir triphosphate and deoxyguanosine triphosphate competitively inhibit herpes simplex virus polymerase, thereby selectively inhibiting the synthesis and inhibition of herpes simplex virus DNA. The generation of herpes simplex virus mutants resistant to this product is due to changes in the properties of viral thymidine deoxynucleoside kinase or DNA polymerase. The most common acyclovir-resistant virus mutants lack thymidine kinase, and they are also resistant to this product.

Ingredients

The main ingredient of this product is: Penciclovir. Its chemical name is: 9-[4-hydroxy-3-(hydroxymethyl)-butyl]-guanine.

Name Description Content CAS NO. Manufacturer
PenciclovirIngredients

This product is a nucleoside antiviral drug, which has an inhibitory effect on type I and type II herpes simplex viruses in vitro. In virus-infected cells, viral thymidine deoxynucleoside kinase phosphorylates this product into penciclovir monophosphate, and then cellular kinase converts penciclovir monophosphate into penciclovir triphosphate. In vitro experiments have shown that penciclovir triphosphate and deoxyguanosine triphosphate competitively inhibit herpes simplex virus polymerase, thereby selectively inhibiting the synthesis and inhibition of herpes simplex virus DNA. The generation of herpes simplex virus mutants resistant to this product is due to changes in the properties of viral thymidine deoxynucleoside kinase or DNA polymerase. The most common acyclovir-resistant virus mutants lack thymidine kinase, and they are also resistant to this product.

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39809-25-1 12

Appearance

This product is a white ointment with an emulsion base.

Indication

Herpes simplex on lips, face, genital herpes.

Usage and Dosage

For external use: Apply to the affected area 4 to 5 times a day. Treatment should be started as soon as possible (if any signs or damage occur).

Adverse Reactions

No systemic adverse reactions were observed, but local burning sensation, pain, and itching were occasionally observed.

Precautions

It is contraindicated for those who are allergic to this product.

Special Population Medication

Precautions for children: Children should use under the guidance of a doctor. Precautions for pregnancy and lactation: Pregnant and lactating women should use under the guidance of a doctor. Precautions for the elderly: Not yet clear.

Drug Interactions

Not yet clear.

Storage

Sealed and stored in a cool place.

Packaging Specification

10g:0.1g

Validity Period

24 months.

Manufacturer

Wuhan Changlian Laifu Pharmaceutical Co., Ltd.

  • Founded in:

    2004-05-19
  • Address:

    No. 12, Jiang'an Road, Jiang'an District, Wuhan
  • Tax NO.:

    91420000761225378J
  • Registered Funds:

    117.7372 million yuan
  • Website:

  • Email:

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