 Home > Encyclopedia > Penciclovir

Penciclovir

Penciclovir structure

CAS No:
39809-25-1
Formula:
C10H15N5O3
Chemical Name:
Penciclovir
Synonyms:
6H-Purin-6-one,2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-;2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one;BRL 39123;Penciclovir;9-[4-Hydroxy-3-(hydroxymethyl)butyl]guanine;VSA 671;Denavir;Penxiluowei;2-Amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-3H-purin-6-one;2-Amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6,9-dihydro-1H-purin-6-one;2-Amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-3,9-dihydropurin-6-one;111790-02-4
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Penciclovir is reported to be potent against HSV types 1 and 2 with IC50 of 0.04-1.8 μg/mL and 0.06-4.4 μg/mL, respectively.

Penciclovir Basic Attributes

Molecular Weight：

253.26

Exact Mass：

253.26

EC Number：

1312995-182-4

Characteristics

PSA：

126

XLogP3：

-1.6

Appearance：

Solid

Density：

1.7±0.1 g/cm3

Melting Point：

275-277 °C

Boiling Point：

653.4°C at 760 mmHg

Flash Point：

338.9±34.3 °C

Refractive Index：

1.749

Water Solubility：

H2O: 1.7mg/ml;0.02 M potassium phosphate: soluble 2mg/mL

Storage Conditions：

-20°C Freezer

Vapor Pressure：

2.98X10-17 mm Hg at 25 deg C (est)

Safety Information

Packing level：

III

Hazard category：

3.2

Transport codes：

UN 1993 3/PG 3

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

UP0789400

Marks：

Precautionary statement(s)：

P264, P280, P305+P351+P338, P33, P313

Hazard Statements：

H319

Penciclovir Use and Manufacturing

A deuterated version of Penciclovir, an antiviral

Drug Function and Efficacy

This product is a nucleoside antiviral drug, which has an inhibitory effect on type I and type II herpes simplex viruses in vitro. In virus-infected cells, viral thymidine deoxynucleoside kinase phosphorylates this product into penciclovir monophosphate, and then cellular kinase converts penciclovir monophosphate into penciclovir triphosphate. In vitro experiments have shown that penciclovir triphosphate and deoxyguanosine triphosphate competitively inhibit herpes simplex virus polymerase, thereby selectively inhibiting the synthesis and inhibition of herpes simplex virus DNA. The generation of herpes simplex virus mutants resistant to this product is due to changes in the properties of viral thymidine deoxynucleoside kinase or DNA polymerase. The most common acyclovir-resistant virus mutants lack thymidine kinase, and they are also resistant to this product.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Penciclovir cream
Ingredients	The main ingredient of this product is: Penciclovir. Its chemical name is: 9-[4-hydroxy-3-(hydroxymethyl)-butyl]-guanine.
Indication	Not yet clear.
Specifications	1.0%
Manufacturer	Hubei Ketian Pharmaceutical Co., Ltd.

Penciclovir for injection
Ingredients	The main ingredient of this product is penciclovir, and the auxiliary materials are low molecular weight dextran and sodium hydroxide. Chemical name: 9-[4-hydroxy-3-(hydroxymethyl)-butyl]guanine. Chemical structure: Molecular formula: C10H15N5O3 Molecular weight: 253.26
Indication	1. When used in combination with interferon or methotrexate (intrathecal), it may cause mental abnormalities and should be used with caution. 2. When used in combination with nephrotoxic drugs, it may aggravate nephrotoxicity, especially in patients with renal insufficiency. 3. When used in combination with zidovudine, it may cause nephrotoxicity, manifested as deep lethargy and fatigue. 4. It competitively inhibits the secretion of organic acids with probenecid. When used in combination with probenecid, it may slow down the excretion of this product, prolong its half-life, and cause drug accumulation in the body.
Specifications	0.25g
Manufacturer	Zhejiang Jianfeng Pharmaceutical Co., Ltd.

Penciclovir cream
Ingredients	The chemical name of penciclovir is 9-[4-hydroxy-3-(hydroxymethyl)-butyl]-guanine.
Indication	Not yet clear.
Specifications	1%((1)2g:20mg(2)5g:50mg(3)10g:0.1g)
Manufacturer	Livzon (GROUP) Pharmaceutical FACTORY

See More Related Drugs

Registered Holders

API PHARMA TECH LLC

United States
Active
MAITHRI DRUGS PRIVATE LTD

United States
Active
ALEMBIC PHARMACEUTICALS LTD

United States
Active

See More Registered Holders

Recommended Suppliers of Penciclovir

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Penciclovir

CAS No.: 39809-25-1

Content: 99.00%

Inquiry
Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

Penciclovir CAS 39809-25-1

CAS No.: 39809-25-1

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
First Chems Co., LTD Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of Titanium dioxide,npk,pvc,sles,labsa,mdi,tdi,Ethylene glycol,p-xylene,mtbe,styrene,Ethyl alcohol,Anthracite (coke),Citric acid,carbinol,toluene,Acetic acid,Dichloroethane,Phenol

Hot Sale Best Price Penciclovir Powder CAS 39809-25-1 with best Price

CAS No.: 39809-25-1

Grade: Food Grade

Content: 99%

Inquiry