Urapidil sustained-release capsules
Function and Efficacy
Urapidil is a highly selective α1 receptor blocker with both peripheral and central effects. The peripheral vasodilator effect is mainly to block postsynaptic α1 receptors, which significantly reduces peripheral resistance. At the same time, it also has a moderate vasoconstrictor effect of blocking catecholamines. The central effect is to reduce blood pressure by stimulating serotonin-1A receptors and reducing the sympathetic feedback regulation of the medullary cardiovascular center. At the same time, it can also improve various hemodynamic indicators by reducing the side effect of reflex heart rate acceleration.
Ingredients
6-[[3-[4-(2-methylaminophenyl)-1-piperazinyl]-propyl]-amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracilIngredients |
Urapidil is a highly selective α1 receptor blocker with both peripheral and central effects. The peripheral vasodilator effect is mainly to block postsynaptic α1 receptors, which significantly reduces peripheral resistance. At the same time, it also has a moderate vasoconstrictor effect of blocking catecholamines. The central effect is to reduce blood pressure by stimulating serotonin-1A receptors and reducing the sympathetic feedback regulation of the medullary cardiovascular center. At the same time, it has no side effect of reflex heart rate acceleration and can also improve various hemodynamic indicators. More |
34661-75-1 | 9 |
Appearance
This product is a capsule, and the contents are off-white to slightly yellow pellets.
Indication
This product is mainly used for essential hypertension, renal hypertension, and hypertension caused by pheochromocytoma.
Usage and Dosage
Adults usually start taking urapidil at 30 mg/day. If the effect is not obvious, the dose can be gradually increased to 60 mg or 120 mg per day over 1 to 2 weeks, taken orally in two doses. The dose can be increased or decreased appropriately based on age and symptoms.
Adverse Reactions
Symptoms may include headache, dizziness, nausea, vomiting, fatigue, palpitations, arrhythmia, itching and insomnia. If the drug is overdose or the dose is increased too quickly in the initial stage of medication, it may cause dizziness, orthostatic hypotension, collapse and fatigue. Symptomatic treatment should be given if necessary.
Precautions
1. People who are allergic to this product. 2. Pregnant and lactating women.
Special Population Medication
Precautions for children: Pregnant and lactating women are prohibited from using this product. Precautions for pregnancy and lactation: Pregnant and lactating women are prohibited from using this product. Precautions for the elderly: Not yet clear.
Drug Interactions
Combination with other antihypertensive drugs can enhance the antihypertensive effect of this drug. Cimetidine can increase the blood concentration of this drug.
Storage
Store at room temperature in a sealed, dry place. The validity period is tentatively 18 months.
Packaging Specification
30mg
Validity Period
24 months
Manufacturer
Xi'an Yuanda Detian Pharmaceutical Co., Ltd.
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Founded in:
2002-12-20 -
Address:
No. 9, Chuangxin Road, New Industrial Park, Xi'an High-tech Industrial Development Zone -
Tax NO.:
91610131742830863Y -
Registered Funds:
82.451 million yuan -
Website:
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Email: