Imipenem and Cilastatin Sodium for Injection

This product is a carbapenem antibiotic. Imipenem has antibacterial effects on Gram-positive and -negative aerobic and anaerobic bacteria. This product is very sensitive to Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus (including enzyme-producing strains), Escherichia coli, Klebsiella, some strains of Acinetobacter, Bacteroides fragilis and other Bacteroides, Peptococcus and some strains of Peptostreptococcus. This product is also quite sensitive to Streptococcus faecalis, Streptococcus epidermidis, Haemophilus influenzae, Proteus mirabilis, Serratia marcescens, Enterobacter aerogenes, Enterobacter cloacae, Pseudomonas aeruginosa, Clostridium difficile, Clostridium difficile, etc. This product has good enzyme resistance and rarely has cross-resistance with other b-lactam drugs.

Imipenem and cilastatin sodium.

This product is white or off-white powder.

This product is used for various infections caused by sensitive bacteria, especially for multiple bacterial complex infections and mixed infections of aerobic and anaerobic bacteria, such as peritonitis, hepatobiliary infection, intra-abdominal abscess, appendicitis, gynecological infection, lower respiratory tract infection, skin and soft tissue infection, urinary tract infection, bone and joint infection and sepsis, etc.

Intravenous drip or intramuscular injection. 1 The dosage is based on imipenem, depending on the condition, 0.25-1g once, 2-4 times a day. For moderate infection, it can generally be given at 1g once, twice a day. Isotonic sodium chloride injection and 5%-10% glucose solution can be used as solvents for intravenous drip. Use 100ml solvent for every 0.5g of drug to make 5mg/ml liquid, and drip it slowly. Use 1% lidocaine injection as solvent for intramuscular injection to relieve pain. 2 For patients with renal insufficiency, the dosage should be adjusted according to creatinine clearance: patients with creatinine clearance of 31-70ml/min, use 0.5g every 6-8 hours, and the maximum daily dose is 1.5-2g; patients with creatinine clearance of 21-30ml/min, use 0.5g every 8-12 hours, and the maximum daily dose is 0.5-1g. Patients with creatinine clearance less than 5ml/min cannot use this product unless the patient undergoes hemodialysis within 48 hours.

1. This product may cause thrombophlebitis if used intravenously at too fast a speed, and may cause local pain, erythema, nodules, etc. when injected intramuscularly. It is advisable to change the injection site. 2. Liver: There may be an increase in aminotransferase, blood bilirubin or alkaline phosphatase. 3. Kidney: There may be an increase in blood creatinine and blood urea nitrogen. However, children can often find red urine when using this drug. This is due to the discoloration caused by the drug, not hematuria. 4. There may be neurological symptoms, such as muscle spasms, mental disorders, etc. 5. This product can cause gastrointestinal symptoms such as nausea, vomiting, diarrhea, and occasionally pseudomembranous colitis. 6. There may be eosinophilia, leukopenia, neutropenia, thrombocytopenia or increase, hemoglobin decrease, etc., and may cause anti-human globulin (Coombs) test

It is contraindicated for those who are allergic to this product.

Precautions for children: There is currently insufficient clinical data to recommend this product for infants under 3 months of age or pediatric patients with renal impairment (serum creatinine> 2mg/dl) (please refer to the "Pediatric Dosage Arrangement" in the Dosage and Administration section). Precautions for pregnancy and lactation: There is no sufficient and well-controlled research data on the use of this product in pregnant women. It can only be administered during pregnancy if the benefits to the fetus outweigh the potential risks. Lactating women: Imipenem can be detected in human milk. If it is determined that it is necessary to use this product in a lactating woman, the patient should stop breastfeeding.

Not yet clear.

Keep in airtight container and away from light.

1.0g (calculated as C12H17N3O4S0.5g and C16H25N2O5S0.5g)

24 months

Han Hui Pharmaceuticals Company Limited

• Founded in:

  2012-09-06

• Address:

  No. 2 Haizheng Road, Xukou Town, Fuyang District, Hangzhou City, Zhejiang Province

• Tax NO.:

  91330100053653670B

• Registered Funds:

  1852.03035908 yuan

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