Diazote suppository

The metronidazole contained in this product is an anti-anaerobic and anti-trichomonal drug; clotrimazole is a broad-spectrum antifungal drug, which has antibacterial effects on various superficial and deep fungi, and its mechanism of action is to inhibit the synthesis of fungal cell membranes and affect their metabolic processes; chlorhexidine acetate is a quaternary ammonium salt cationic surfactant, which has a bactericidal effect on Gram-positive bacteria. The combination of the three drugs has a synergistic effect, which is not only suitable for simple fungal, bacterial or trichomonal infections, but also for mixed infections.

This product is a compound preparation. Each tablet contains the main ingredients: metronidazole 200 mg, clotrimazole 160 mg, and chlorhexidine acetate 8 mg.

This product is an off-white to creamy yellow suppository.

Used for bacterial vaginosis, candidal vulvovaginitis, trichomoniasis, and mixed bacterial, fungal and trichomoniasis vaginitis.

For vaginal administration, wash your hands before going to bed, take the suppository, remove the outer packaging, put on a finger cot, and insert the product deep into the vagina (posterior fornix), 1 capsule each time, 7 consecutive days as a course of treatment. Repeat the course of treatment after the first menstruation after stopping the drug.

Occasionally, skin rash, vaginal burning sensation, itching or other mucosal irritation symptoms may occur. Because this product can be absorbed from the mucosa, long-term and large-scale use may also produce the same adverse reactions as systemic medication, such as nausea, loss of appetite, vomiting, diarrhea, abdominal discomfort, taste changes, dry mouth, metallic taste in the mouth, etc. Epileptic seizures and peripheral neuropathy, the latter mainly manifested as numbness and paresthesia of the extremities. Others include reversible neutropenia. Allergic reactions such as rash, urticaria, itching, etc. Central nervous system symptoms such as headache, dizziness, syncope, paresthesia, limb numbness, ataxia and mental confusion. Elevated serum aminotransferase, fever, cystitis, dysuria, dark urine, etc. are all reversible and will recover on their own after stopping the drug.

1. Patients allergic to azole (imidazole) drugs are prohibited from using this product. 2. Patients with active central nervous system diseases and blood diseases are prohibited from using this product. 3. Pregnant women are prohibited from using this product.

Precautions for children: Children should use with caution. Precautions for pregnancy and lactation: Animal experiments have found that metronidazole and clotrimazole are toxic to the fetus after intraperitoneal or oral administration. However, there is currently a lack of sufficient and rigorous controlled studies on pregnant and lactating women. Therefore, pregnant women are prohibited from using this product, and lactating women should stop breastfeeding when using this product. Precautions for the elderly: Due to decreased liver function, the pharmacokinetics of this product are changed when the elderly use it, so it should be used with caution.

1 Chlorhexidine is incompatible with soap, potassium iodide, etc. It is also incompatible with borax, bicarbonate, carbonate, oxide, citrate, phosphate and sulfate. 2 When this product is used in combination with oxytetracycline, the latter may interfere with the effect of metronidazole in clearing vaginal Trichomonas. 3 Long-term and large-scale use, after absorption through the mucosa, may also produce drug interactions similar to systemic medications, such as inhibiting the metabolism of warfarin and other oral anticoagulants, interfering with disulfiram metabolism and serum aminotransferase and lactate dehydrogenase assay results, and combining with liver microsomal enzyme inducers or inhibitors to speed up or slow down the metabolism of this product in the liver. 4 Drug interactions may occur if used with other drugs. Please consult a physician or pharmacist for details.

Keep in a dark place, tightly sealed and store below 30°C.

Compound

24 months.

Huludao Guodi Pharmaceutical Co., Ltd.

• Founded in:

  2000-06-29

• Address:

  Huludao Gaoqiao Economic Development Zone

• Tax NO.:

  91211404123720542A

• Registered Funds:

  16.18 million yuan

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