Ceftiofiorin Hydrochloride for Injection
Function and Efficacy
This product is a second-generation cephalosporin antibiotic. Its effect on Gram-positive bacteria is similar to that of cefazolin, but it is more effective against Gram-negative bacteria, such as Haemophilus, Escherichia coli, Klebsiella, Proteus mirabilis, etc. It also has antibacterial effects on Enterobacter, Citrobacter, indole-positive Proteus, etc. Its mechanism of action is to bind to penicillin-binding proteins (PBPs) on the bacterial cell membrane, acylate transpeptidase, inhibit the synthesis of bacterial septum and cell wall, affect the cross-linking of cell wall mucopeptide components, inhibit cell division and growth, elongate the bacterial morphology, and finally dissolve and die.
Ingredients
The main ingredient of this product is ceftriaxone hydrochloride.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Cefotiam hydrochlorideIngredients |
This product is a second-generation cephalosporin antibiotic. Its effect on Gram-positive bacteria is similar to that of cefazolin, but it is more effective against Gram-negative bacteria, such as Haemophilus, Escherichia coli, Klebsiella, Proteus mirabilis, etc. It also has antibacterial effects on Enterobacter, Citrobacter, indole-positive Proteus, etc. Its mechanism of action is to bind to penicillin-binding proteins (PBPs) on the bacterial cell membrane, acylate transpeptidase, inhibit the synthesis of bacterial septum and cell wall, affect the cross-linking of cell wall mucopeptide components, inhibit cell division and growth, elongate the bacterial morphology, and finally dissolve and die. More |
66309-69-1 | 14 |
Appearance
This product is white or slightly yellow powder.
Indication
Used to treat infections caused by sensitive bacteria, such as pneumonia, bronchitis, bile duct infection, peritonitis,
Usage and Dosage
Usually, adults take 0.5-2g a day, divided into 2-4 times; children take 40-80mg/kg a day, divided into 3-4 times, intravenously. This product can be appropriately increased or decreased according to age and symptoms. The daily dose can be increased to 4g for adults with sepsis, and can be increased to 160mg for children with severe and refractory infections such as sepsis and meningitis. For intravenous injection, it can be dissolved in normal saline or glucose injection solution before use. In addition, a single dose of 0.25-2g of this product can be added to sugar solution, electrolyte solution or amino acid infusion and intravenously dripped within 30 minutes to 2 hours. For children, refer to the dosage described above, add it to the rehydration and drip it intravenously within 30 minutes to 1 hour.
Adverse Reactions
Allergic reactions, gastrointestinal reactions, changes in blood counts, and transient elevations in serum aminotransferases may occur occasionally. Changes in intestinal flora may result in vitamin B and K deficiencies. Secondary infections may occur occasionally. Large amounts of intravenous injection may cause vascular pain and thrombophlebitis.
Precautions
It is contraindicated in patients who are allergic to cephalosporin antibiotics.
Drug Interactions
1. It is generally believed that there is a synergistic effect when used in combination with aminoglycoside antibiotics, but it may aggravate renal damage. Administration in the same container may affect the potency of the drug. 2. It may cause renal damage when used in combination with strong diuretics such as furosemide.
Packaging Specification
1.0g (calculated as cefotiam C18H23N9O4S3)
Manufacturer
Shanghai SPH New ASIA Pharmaceutical Co., Ltd.
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Founded in:
1993-08-11 -
Address:
No. 978 Chuansha Road, Pudong New Area, Shanghai -
Tax NO.:
91310115133738906M -
Registered Funds:
1,052,429,132 yuan -
Website:
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Email: