Sodium valproate syrup

1. This product can inhibit the metabolism of phenytoin sodium, phenobarbital, primidone, and clonazepam, which can easily lead to poisoning. Therefore, the dosage should be adjusted when used in combination. 2. Drinking alcohol can aggravate the sedative effect. Avoid drinking alcohol during medication. 3. When used in combination with anticoagulants such as warfarin or heparin, as well as thrombolytic drugs, the risk of bleeding increases. 4. When used in combination with aspirin or dipyridamole, it can prolong bleeding time due to reduced platelet aggregation. 5. When used in combination with carbamazepine, the induction of liver enzymes can accelerate drug metabolism, which can reduce the blood concentration and half-life of the two drugs. Therefore, the blood concentration must be monitored to determine whether the dosage needs to be adjusted. 6. When used in combination with haloperidol, loxapine, maprotiline, monoamine oxidase inhibitors, phenothiazines, thioxanthenes, and tricyclic antidepressants, it can increase the inhibition of the central nervous system, reduce the convulsion threshold and the effect of valproic acid, and the dosage must be adjusted in time to control the attack.

Sodium valproate

This product is a light yellow clear liquid; it tastes sweet with a slight astringency.

This product is mainly used for simple or complex absence seizures, myoclonic seizures and generalized tonic-clonic seizures (grand mal seizures) of epilepsy. It also has a certain effect on complex partial seizures.

Oral: 1 Common dosage for adults: 15 mg/kg per day or 600-1200 mg per day, divided into two doses. Start with 5-10 mg/kg per day, increase gradually after one week until the attack is controlled. When the daily dosage exceeds 250 mg, it should be taken in divided doses to reduce gastrointestinal irritation. The maximum dosage is generally no more than 30 mg/kg per day, or 1.8-2.4 g per day. 2 Common dosage for children: The same as that for adults, based on body weight. There are also reports that the dosage is 15 mg/kg per day, and 5-10 mg/kg is increased every other week as needed until it is effective or cannot be tolerated.

1. Rare: (1) Allergic rash. (2) Thrombocytopenia or platelet aggregation inhibition leading to abnormal bleeding or ecchymosis. (3) Liver poisoning with yellowing of eyes and skin. 2. The following reactions should be noted if they persist. (1) More common: diarrhea, indigestion, nausea or vomiting, gastrointestinal spasm, menstrual cycle changes. (2) Less common or rare: constipation, drowsiness, generally mild and temporary hair loss, dizziness, fatigue, headache, ataxia, abnormal excitement, restlessness and irritability.

1. This product can penetrate the placenta barrier. Animal experiments have reported teratogenicity, but this has not been confirmed in humans. Pregnant women need to weigh the pros and cons when using it. 2. Lactating women need to weigh the pros and cons when using it.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: 1. This product can penetrate the placental barrier. There are reports of teratogenicity in animal experiments, but it has not been confirmed in humans. Pregnant women need to weigh the pros and cons when using it. 2. Pregnant women need to weigh the pros and cons when using it. Precautions for the elderly: Not yet clear.

1. This product can inhibit the metabolism of phenytoin sodium, phenobarbital, primidone, and clonazepam, which can easily lead to poisoning. Therefore, the dosage should be adjusted when used in combination. 2. Drinking alcohol can aggravate the sedative effect. Avoid drinking alcohol during medication. 3. When used in combination with anticoagulants such as warfarin or heparin, as well as thrombolytic drugs, the risk of bleeding increases. 4. When used in combination with aspirin or dipyridamole, it can prolong bleeding time due to reduced platelet aggregation. 5. When used in combination with carbamazepine, the induction of liver enzymes can accelerate drug metabolism, which can reduce the blood concentration and half-life of the two drugs. Therefore, the blood concentration must be monitored to determine whether the dosage needs to be adjusted. 6. When used in combination with haloperidol, loxapine, maprotiline, monoamine oxidase inhibitors, phenothiazines, thioxanthenes, and tricyclic antidepressants, it can increase the inhibition of the central nervous system, reduce the convulsion threshold and the effect of valproic acid, and the dosage must be adjusted in time to control the attack.

Sealed, store in a dry place.

24 months

Hunan Xiangzhong Pharmaceutical Co., Ltd.

• Founded in:

  1998-03-05

• Address:

  No. 18, Daxing South Road, Baoqing Industrial Concentration Zone, Shaoyang City, Hunan Province

• Tax NO.:

  91430500185569358T

• Registered Funds:

  69 million yuan

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