Tamoxifen Citrate Tablets

Tamoxifen is a non-steroidal anti-estrogen drug. Its structure is similar to that of estrogen, and there are two isomers, Z and E. The two have different physical and chemical properties and physiological activities. The E type has weak estrogen activity, while the Z type has anti-estrogen effects. If there are estrogen receptors (ER) in breast cancer cells, estrogen enters the tumor cells and binds to them, promoting the synthesis of DNA and m-RNA in the tumor cells and stimulating the growth of tumor cells. The Z-isomer of tamoxifen enters the cells, competes with ER for binding, forms a receptor complex, and prevents the effect of estrogen, thereby inhibiting the proliferation of breast cancer cells.

The main chemical component of this product is tamoxifen citrate. The chemical name is: (Z)-N, N-dimethyl-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-ethylamine citrate. Molecular formula: C26H29NOC6H8O7. Molecular weight: 563.65

This product is white tablets.

1. Treat recurrent and metastatic breast cancer in women; 2. Used as an adjuvant treatment for metastatic breast cancer after surgery to prevent recurrence.

Take 10 mg orally twice a day, or 20 mg twice a day.

Bone and tumor pain may be transiently aggravated at the beginning of treatment, and gradually alleviated with continued treatment. A small number of patients have adverse reactions. Gastrointestinal reactions: loss of appetite, nausea, vomiting, diarrhea; reproductive system: menstrual disorders, amenorrhea, vaginal bleeding, vulvar itching, endometrial hyperplasia, endometrial polyps and endometrial cancer; skin: facial flushing, rash, hair loss. Bone marrow: occasional leukopenia and thrombocytopenia; liver function: occasional abnormalities; eyes: long-term (more than 17 months) and large amounts (240-320 mg per day) use may cause retinopathy or corneal opacity. Rare adverse reactions that require attention: mental confusion, pulmonary embolism (manifested as shortness of breath), thrombosis, weakness, and drowsiness.

It is contraindicated for patients with fundus diseases.

Precautions for children: This experiment has not been conducted and there is no reliable reference. Precautions for pregnancy and lactation: It has an impact on the fetus and is contraindicated for pregnant and lactating women. Precautions for the elderly: This experiment has not been conducted and there is no reliable reference.

Estrogen can affect the therapeutic effect of this product; antacids, cimetidine, ranitidine, etc. change the pH value in the stomach, causing the enteric coating of this product to decompose prematurely, which has a stimulating effect on the stomach.

Keep in a light-proof and airtight storage place.

10mg (calculated as tamoxifen)

24 months

Shanghai Fudan Fuhua Pharmaceutical Co., Ltd.

• Founded in:

  1981-12-01

• Address:

  No. 1399 Shuguang Road, Minhang District, Shanghai

• Tax NO.:

  91310112132661556L

• Registered Funds:

  44.8 million yuan

• Email:

  Log in to view