Piperazine Citrate Tablets

Piperazine has the effect of paralyzing the muscles of roundworms. Its mechanism may be that piperazine exerts an anticholinergic effect at the neuromuscular junction of the worm body, blocks the excitatory effect of acetylcholine on the muscles of roundworms, or changes the permeability of the muscle cell membrane of the worm body to ions, affecting the transmission of nerve impulses; it can also inhibit the production of succinate, reduce the supply of energy, block the neuromuscular junction, and prevent the impulse from being transmitted. As a result, the roundworms are detached from the parasitic site and excreted from the body with intestinal peristalsis. Ascaris does not show excitatory effects before paralysis, so it is safer to use this product. This product has no effect on roundworm larvae, and its effect on the muscles of mammals is also very weak. Its mechanism of action on pinworms is not yet clear.

Piperazine Citrate

This product is white tablets.

For roundworm and pinworm infections.

Oral administration, no fasting required, no need to add cathartics except for those with constipation. 1. The usual dose for adults to remove roundworms is 3~3.5g once, taken before bedtime, for 2 consecutive days. For children, take 0.15g/kg once according to body weight, no more than 3g per day, taken before bedtime, for 2 consecutive days. 2. The usual dose for adults to remove pinworms is 2~2.5g per day, divided into 2 doses, for 7~10 consecutive days. For children, take 60mg/kg per day according to body weight, divided into 2 doses, no more than 2g per day, for 7~10 consecutive days.

This product has low toxicity and mild side effects. It may occasionally cause nausea, vomiting, diarrhea, headache, paresthesia, urticaria, etc., which disappear quickly after stopping the drug. Allergic people may experience tearing, runny nose, cough, dizziness, drowsiness, asthma, etc. Cataract formation and hemolytic anemia (seen in people with glucose-6-phosphate dehydrogenase deficiency) are rare.

It is contraindicated for patients with liver and kidney dysfunction, neurological diseases or a history of allergy to this product.

Precautions for children: This product has potential neuromuscular toxicity to children, and long-term or excessive use should be avoided. Precautions during pregnancy and lactation: Not yet clear.

1. This product may cause convulsions when used together with chlorpromazine, so it should be avoided. 2. It has an antagonistic effect when used together with pyrantel. 3. After animals take piperazine and nitrite orally, piperazine can be converted into nitroso compounds in the stomach to form N, N-dinitropiperazine or N-mononitropiperazine, both of which are carcinogens for animals. After healthy non-smoking men were given piperazine syrup (containing 480 mg) orally on an empty stomach, a considerable amount of N-mononitropiperazine was also detected in their gastric juice and excreted in the urine, but N, N-dinitropiperazine was not found.

Keep away from light and store in sealed container.

0.25g

24 months

Jilin Yatai Pharmaceutical Co., Ltd.

• Founded in:

  1999-09-07

• Address:

  No. 8000, Beiyuanda Street, High-tech Development Zone, Changchun City, Jilin Province

• Tax NO.:

  91220000715393231E

• Registered Funds:

  83.150448 million yuan

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