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Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2), hydrate

Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2), hydrate structure

CAS No:
41372-10-5
Formula:
C6H8O7.³/2C4H10N2.xH2O
Chemical Name:
Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2), hydrate
Synonyms:
Piperazine,2-hydroxy-1,2,3-propanetricarboxylate (3:2),hydrate
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

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Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2), hydrate Basic Attributes

Molecular Weight：

660.67

Exact Mass：

660.317749

EC Number：

232-366-4

Characteristics

PSA：

382.59000

XLogP3：

-3.30810

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

65-36/37/38

safety instructions：

23-24-62-26

Marks：

Xn,Xi

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

H315-H319-H335

Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2), hydrate Use and Manufacturing

It is indicated as alternative treatment for ascariasis caused by roundworm and enterobiasis caused by pinworm.

Drug Function and Efficacy

Piperazine has the effect of paralyzing the muscles of roundworms. Its mechanism may be that piperazine exerts an anticholinergic effect at the neuromuscular junction of the worm body, blocks the excitatory effect of acetylcholine on the muscles of roundworms, or changes the permeability of the muscle cell membrane of the worm body to ions, affecting the transmission of nerve impulses; it can also inhibit the production of succinate, reduce the supply of energy, block the neuromuscular junction, and prevent the impulse from being delivered. As a result, the roundworms are detached from the parasitic site and excreted from the body with intestinal peristalsis. Ascaris does not show excitatory effects before paralysis, so it is safer to use this product. This product has no effect on roundworm larvae, and its effect on the muscles of mammals is also very weak. Its mechanism of action on pinworms is not yet clear.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Piperazine Citrate Syrup
Ingredients	The main ingredients of this product are: Piperazine citrate. Molecular formula: (C4H10N2)3·2C6H8O7·5H2O Molecular weight: 732.74
Indication	1. This product may cause convulsions when used together with chlorpromazine, so it should be avoided. 2. It has an antagonistic effect when used together with pyrantel. 3. After animals take piperazine and nitrite orally, piperazine can be converted into nitroso compounds in the stomach to form N, N-dinitropiperazine or N-mononitropiperazine, both of which are carcinogens for animals. After healthy non-smoking men were given piperazine syrup (containing 480 mg) orally on an empty stomach, a considerable amount of N-mononitropiperazine was also detected in their gastric juice and excreted in the urine, but N, N-dinitropiperazine was not found.
Specifications	100ml:16g
Manufacturer	Hunan Hengsheng Pharmaceutical Co., Ltd.

Piperazine Citrate Tablets
Ingredients	Piperazine Citrate
Indication	1. This product may cause convulsions when used together with chlorpromazine, so it should be avoided. 2. It has an antagonistic effect when used together with pyrantel. 3. After animals take piperazine and nitrite orally, piperazine can be converted into nitroso compounds in the stomach to form N, N-dinitropiperazine or N-mononitropiperazine, both of which are carcinogens for animals. After healthy non-smoking men were given piperazine syrup (containing 480 mg) orally on an empty stomach, a considerable amount of N-mononitropiperazine was also detected in their gastric juice and excreted in the urine, but N, N-dinitropiperazine was not found.
Specifications	0.25g
Manufacturer	Jilin Yatai Pharmaceutical Co., Ltd.

Piperazine Citrate Granules
Ingredients	The main ingredients of this product are: piperazine citrate. Molecular weight: (C4H10N2)3·2C6H8O7·5H2O
Indication	1. This product may cause convulsions when used with chlorpromazine, so it should be avoided. 2. This product has an antagonistic effect when used with pyrantel, so it should be avoided. 3. If used with other drugs at the same time, drug interactions may occur. Please consult a doctor or pharmacist for details.
Specifications	Each gram contains 0.16 g of piperazine citrate
Manufacturer	Shaanxi Traditional Chinese Medicine Research Institute Hantang Pharmaceutical C O., Ltd.

See More Related Drugs

Registered Holders

Chongqing Qingyang Pharmaceutical Co., Ltd.

China
Active
Sinopharm Shantou Jinshi Pharmaceutical Co., Ltd.

China
Active

Recommended Suppliers of Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2), hydrate

bazayan Enterprises LLP Contact Supplier

IN
9 YRS

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Piperazine Citrate

CAS No.: 41372-10-5

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Xi'an Veda Chemical Contact Supplier

CN
1 YR

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Manufactory Supplier of Methyl 3-aminocrotonate,Ethyl 3-aminocrotonate,N-Hydroxyethyl phthalimide,N-Hydroxymethyl phthalimide,N-Hydroxy Phthalimide,Amidinothiourea,Diacetonefructose,N-Acetylglycine,1,6-Hexamethylene-Bis-Cyanoguanidine,Cyclopropanethrocarboxamide,Guanidine Hydrochloride,Guanidine Carbonate,Methotrexate,Berberine Hydrochloride,Methylthiouracil,Lomustine,Piperazine Citrate,Chlorhexidine Gluconate,Chlorhexidine Acetate,Ammonium 1-pyrrolidinethiocarbamate,Polyhexamethylene Biguanidine Hydrochloride,Etidronate Disodium,Tetrasodium Etidronate,Ethacridine Lactate,Pyridine Sulfur Trioxide,Methyl phenylacetate,Sieber Linker,Chlorhexidine

p iperazine citrate manufacturer

Unit Price: $15-17 /KG FOB

CAS No.: 41372-10-5

Grade: Pharmaceutical Grade

Content: 98%

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Hangzhou Chungyo Chemicals Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals

PIPERAZINE CITRATE HYDRATE

CAS No.: 41372-10-5

Grade: Industrial Grade

Content: 98%

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Guide of Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2), hydrate

Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2), hydrate

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