Betamethasone Tablets

Glucocorticoid drugs. They have multiple pharmacological effects such as anti-inflammatory, anti-allergic and immunosuppressive, and are widely used in clinical practice. 1. Anti-inflammatory effect. Glucocorticoids reduce and prevent tissue responses to inflammation, thereby reducing the manifestations of inflammation. 2. Immunosuppressive effect. Prevent or inhibit cell-mediated immune responses, delayed allergic reactions, reduce the number of T lymphocytes, monocytes and eosinophils, reduce the binding ability of immunoglobulins to cell surface receptors, and inhibit the synthesis and release of interleukins, thereby reducing the transformation of T cells into lymphoblasts and reducing the expansion of primary immune responses. 3. Anti-toxic and anti-shock effects. Glucocorticoids can counteract the stimulation of bacterial endotoxins on the body, reduce cell damage, and play a role in protecting the body.

The main ingredient of this product is betamethasone. Molecular formula: C22H29FO5 Molecular weight: 392.47

This product is white tablets.

It is mainly used for allergic and autoimmune inflammatory diseases. It is now mostly used for active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, acute leukemia, etc. It is also used for the comprehensive treatment of certain infections.

The initial oral dose is 1-4 mg per day, given in divided doses. The maintenance dose is 0.5-1 mg per day.

There are no obvious adverse reactions when glucocorticoids are used for replacement therapy with physiological doses. Adverse reactions mostly occur when pharmacological doses are used, and are closely related to the course of treatment, dosage, type of medication, usage and route of administration. Common adverse reactions are as follows: 1. Long-term use may cause the following side effects. Iatrogenic Cushing's syndrome facial and body shape, weight gain, lower limb edema, purple lines, bleeding tendency, poor wound healing, acne, menstrual disorders, avascular necrosis of the humeral or femoral head, osteoporosis and fractures (including vertebral compression fractures, long bone pathological fractures), muscle weakness, muscle atrophy, hypokalemia syndrome, gastrointestinal irritation (nausea, vomiting), pancreatitis, peptic ulcer or perforation, growth inhibition in children, glaucoma, cataracts, benign intracranial hypertension syndrome, impaired glucose tolerance and aggravation of diabetes. 2. Patients may experience mental symptoms. Euphoria, agitation, delirium, restlessness, disorientation, and inhibition may also be manifested. Mental symptoms are prone to occur in people with chronic wasting diseases and those who have had mental disorders in the past. 3 Concurrent infection is the main adverse reaction of adrenocortical hormones. Mainly fungi, tuberculosis, staphylococcus, Proteus, Pseudomonas aeruginosa and various herpes viruses. 4 Corticosteroid withdrawal syndrome. Sometimes patients experience dizziness, fainting tendency, abdominal pain or back pain, low fever, loss of appetite, nausea, vomiting, muscle or joint pain, headache, fatigue, weakness after stopping the drug. If careful examination can rule out adrenocortical insufficiency and recurrence of the original disease, it can be considered as a syndrome of dependence on glucocorticoids.

Patients who are allergic to this product or other steroid hormones are prohibited from using it. Patients with the following diseases should not use it in general. In special cases, the pros and cons should be weighed, but attention should be paid to the possibility of worsening of the condition: severe mental illness (past or present) and epilepsy, active peptic ulcer disease, recent gastrointestinal anastomosis, fractures, trauma repair period, corneal ulcer, hyperadrenocortical syndrome, hypertension, diabetes, pregnant women, infections that cannot be controlled by antibacterial drugs such as chickenpox, measles, fungal infections, severe osteoporosis, etc.

Precautions for children: Children should be very cautious when using adrenocortical hormones for a long time. Precautions for pregnancy and lactation: Generally not suitable for use. Precautions for the elderly: Elderly patients are prone to hypertension and diabetes when using glucocorticoids. Elderly patients, especially postmenopausal women, are prone to aggravating osteoporosis when using glucocorticoids.

1. Nonsteroidal anti-inflammatory analgesics can enhance its ulcerogenic effect. 2. It can enhance the hepatotoxicity of acetaminophen. 3. When used in combination with amphotericin B or carbonic anhydrase inhibitors, it can aggravate hypokalemia. Long-term use with carbonic anhydrase inhibitors can easily lead to hypocalcemia and osteoporosis. 4. When used in combination with protein anabolic hormones, it can increase the incidence of edema and aggravate acne. 5. Long-term use with anticholinergics (such as atropine) can cause increased intraocular pressure. 6. Tricyclic antidepressants can aggravate the mental symptoms caused by it. 7. When used in combination with hypoglycemic drugs such as insulin, the dose of hypoglycemic drugs should be appropriately adjusted because it can increase blood sugar in diabetic patients. 8. Thyroid hormones can increase its metabolic clearance rate, so when thyroid hormones or antithyroid drugs are used in combination with it, the dose of the latter should be appropriately adjusted. 9. When used in combination with contraceptives or estrogen preparations, it can enhance its therapeutic effects and adverse reactions. 10. When used in combination with cardiac glycosides, it can increase the occurrence of digitalis toxicity and arrhythmia. 11 When used in combination with potassium-excreting diuretics, it can cause severe hypokalemia and weaken the sodium-excreting and diuretic effects of diuretics due to water and sodium retention. 12 When used in combination with ephedrine, its metabolic clearance can be enhanced. 13 When used in combination with immunosuppressants, it can increase the risk of infection and may induce lymphoma or other lymphoproliferative diseases. 14 It can increase the metabolism and excretion of isoniazid in the liver, and reduce the blood concentration and efficacy of isoniazid. 15 It can promote the metabolism of mexiletine in the body and reduce the blood concentration. 16 When used in combination with salicylates, it can reduce the concentration of plasma salicylate. 17 When used in combination with growth hormone, it can inhibit the latter's growth-promoting effect.

Keep away from light and store in sealed container.

0.5mg

36 months