Cisapride Tablets

This product is a whole gastrointestinal tract motility drug, which can enhance esophageal peristalsis and lower esophageal sphincter tension, prevent gastric contents from reflux into the esophagus, and improve esophageal clearance; increase gastric and duodenal contractility and coordination of gastric antrum and duodenum; reduce duodenal and gastric reflux, improve gastric and duodenal emptying; strengthen intestinal movement and promote small and large intestine transit. This product does not increase the basal and pentagastrin-induced gastric acid secretion. In addition, it has almost no effect on plasma prolactin levels.

The main ingredient of this product is cisapride, whose chemical name is cis-4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-pyridyl]-2-methoxyaniline.

White flakes.

1. Increase gastrointestinal motility. It can be used for gastroparesis syndrome, or upper gastrointestinal discomfort, but the symptom group with negative X-ray and endoscopic examinations, characterized by early satiety, fullness after meals, decreased food intake, bloating, excessive belching, lack of appetite, nausea, vomiting or ulcer-like complaints (burning pain in the upper abdomen); 2. Gastroesophageal reflux, including the treatment and maintenance of esophagitis; 3. Insufficient propulsive peristalsis and retention of gastrointestinal contents caused by pseudo-intestinal obstruction related to motility disorders; 4. To restore the propulsive motility of the colon, as a long-term treatment for patients with chronic constipation.

Oral administration: the total daily dose for adults is 15-40 mg, divided into 2-4 times, depending on the condition. (1) General condition: 5 mg once, 3 times a day. (2) Severe condition: (gastroparesis, esophagitis, intractable constipation) 10 mg once, 3 times a day, or 10 mg once, 4 times a day, before meals and before bedtime. Or 20 mg once, 2 times a day, before breakfast and before bedtime. (3) Maintenance treatment of esophagitis: 10 mg once, 2 times a day (before breakfast and before bedtime) or 20 mg once a day (before bedtime). The dose can be doubled for patients with severe conditions. (4) For the treatment of upper gastrointestinal dysfunction, it should be taken at least 15 minutes before meals and at an appropriate time before bedtime with certain drinks. (5) For the treatment of constipation, the total daily dose should be taken in two doses.

1. Occasionally, transient abdominal cramps, borborygmus, and diarrhea may occur. The dose may be halved. 2. Occasionally, allergies, mild transient headaches or dizziness, and dose-related frequent urination have been reported. 3) Rare reversible liver function abnormalities may occur, with or without cholestasis. 4. Male breast feminization and galactorrhea, the incidence in large-scale monitoring studies (<0.1%) did not exceed the common value of the general population, and it is reversible after discontinuation of the drug. The causal relationship is not clear. 5. Rarely, it affects the central nervous system, namely convulsive epilepsy, extrapyramidal reactions, and frequent urination.

1. Patients with known allergy to this product are prohibited from taking it orally or parenterally at the same time as ketoconazole, itraconazole, miconazole, fluconazole, erythromycin, clarithromycin or troleandomycin.

Precautions for children: Premature infants less than 34 weeks of gestation should be used with caution. Precautions for pregnancy and lactation: 1. Although it does not affect embryo formation in animals, has no original embryo toxicity, and has no teratogenic effect, if it is used during pregnancy, especially in the first three months of pregnancy, the pros and cons should be weighed. 2. Although the amount excreted through breast milk is very small, it is still recommended that breastfeeding mothers do not use it. Precautions for the elderly: In the elderly, due to the moderate extension of the elimination half-life, the steady-state plasma concentration will generally increase, so the therapeutic dose should be reduced as appropriate.

(1) This product is a strong inhibitor of CYP3A4, so it should not be used with drugs that are mainly metabolized by CYP3A4, such as imidazoles, macrolides, etc., to avoid serious adverse reactions. (2) This product can accelerate gastric emptying of drugs, reduce the absorption rate of drugs absorbed through the stomach, and increase the absorption rate of drugs absorbed through the intestine.

Store in a dry place at 15-30℃, out of reach of children.

5mg

24 months

Shandong Qikang Pharmaceutical Co., Ltd.

• Founded in:

  2004-04-23

• Address:

  West of Yingbin Road, Yucheng City, Dezhou City, Shandong Province

• Tax NO.:

  91371482762869845U

• Registered Funds:

  10 million yuan

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