Azlocillin Sodium for Injection

This product is a semi-synthetic penicillin, which has good antibacterial effect on Gram-positive bacteria, Gram-negative bacteria and Pseudomonas aeruginosa. It can produce synergistic effect when used in combination with amikacin, gentamicin and netilmicin.

Azlocillin sodium.

This product is white or off-white powder or loose lumps.

It is mainly used for various infections caused by sensitive Gram-positive and Gram-negative bacteria and Pseudomonas aeruginosa infections, including sepsis, meningitis, endocarditis, purulent pleurisy, peritonitis and infections of the lower respiratory tract, gastrointestinal tract, bile duct, urinary tract, bone and soft tissue and reproductive organs, gynecological and obstetric infections, malignant otitis externa, burns, skin and surgical infections, etc.

Add to appropriate amount of 5% glucose sodium chloride injection or 5-10% glucose injection, and drip intravenously. Adults take 6-10g a day, and in severe cases, it can be increased to 10-16g, usually dripped in 2-4 times. Children take 75mg/kg per time according to body weight, and infants and newborns take 100mg/kg per time according to body weight, dripped in 2-4 times.

Adverse reactions similar to those of penicillin are mainly allergic reactions (such as itching, urticaria, etc.). Other reactions include diarrhea, nausea, vomiting, fever, and in some cases, prolonged bleeding time and leukocytopenia may be seen. Electrolyte disorders (hypernatremia) are less common.

It is contraindicated for patients who are allergic to penicillin antibiotics.

1. Chloramphenicol, erythromycin, tetracycline and other antibiotics and sulfonamides and other antibacterial agents can interfere with the bactericidal activity of this product and should not be used in combination with this product, especially in the treatment of meningitis or severe infections that urgently require bactericides. 2. Probenecid, aspirin, indomethacin, phenylbutazone and sulfonamides can reduce the excretion of this product from the kidneys, so when used in combination with this product, its blood concentration will increase, the excretion time will be prolonged, and the toxicity may also increase. 3. This product is incompatible with heavy metals, especially copper, zinc and mercury, because the latter can destroy its oxidized thiazole ring. Rubber tubes or bottle stoppers made of zinc compounds can also affect its activity. Acidic glucose injection or tetracycline injection can destroy its activity. It can also be inactivated by oxidants, reducing agents or hydroxyl compounds. 4. This product will become turbid after adding cephalothin, lincomycin, tetracycline, vancomycin, erythromycin ethylsuccinate, amphotericin B, norepinephrine, metaraminol, phenytoin sodium, hydroxyzine hydrochloride, prochlorperazine, promethazine, vitamin B group, vitamin C, etc. to the intravenous infusion. 5. This product can enhance the effect of warfarin 6. After this product is mixed with aminoglycoside antibiotics, the antibacterial activity of both is significantly weakened, so the two drugs cannot be placed in the same container for administration. 7. This product can slow down the clearance of cefotaxime and ciprofloxacin from the body, so the doses of the latter two should be reduced when used together.

Store in airtight, dry place.

1.5g (calculated as C20H23N5O6S)

ZHONGFU Pharmaceutical Co., Ltd.

• Founded in:

  2000-04-22

• Address:

  No. 2709, Yuwang North Street, Hanting District, Weifang City, Shandong Province

• Tax NO.:

  913707037232674976

• Registered Funds:

  78.364 million yuan

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