Cefaclor Dispersible Tablets

This product is a broad-spectrum semi-synthetic cephalosporin antibiotic. Its activity against penicillinase-producing Staphylococcus aureus, group A hemolytic streptococci, viridans streptococci and Staphylococcus epidermidis is the same as that of cefadroxil, and its antibacterial effect against non-enzyme-producing Staphylococcus aureus and pneumococci is 2 to 4 times stronger than that of cefadroxil. Its activity against Gram-negative bacilli, including Escherichia coli and Klebsiella pneumoniae, is stronger than that of cefadroxil, and is similar to that of cefadroxil. Its activity against Proteus mirabilis, Salmonella and Shigella is stronger than that of cefadroxil. 2.9 to 8 mg/L of this product can inhibit all Haemophilus influenzae, including strains resistant to ampicillin. Moraxella catarrhalis and Neisseria gonorrhoeae are very sensitive to this product. Indole-positive Proteus, Serratia, Acinetobacter and Pseudomonas aeruginosa are all resistant to this product. The mechanism of action of this product is to inhibit the synthesis of bacterial cell walls.

The main ingredient is cefaclor: (6R,7R)-7-[(R)-2-amino-2-phenylacetylamino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate

This product is a film-coated tablet, which is off-white to light yellow in color after removing the coating.

It is mainly suitable for respiratory tract infections caused by sensitive bacteria such as pneumonia, bronchitis, pharyngitis, tonsillitis, etc.; otitis media; sinusitis; urinary tract infections such as gonorrhea, pyelonephritis, cystitis; skin and skin tissue infections, etc.; bile tract infections, etc.; the efficacy of this product in treating group A hemolytic streptococcal pharyngitis and tonsillitis is similar to that of penicillin V.

Oral administration. Adults: 0.25g once, 3 times a day. The dose can be doubled for patients with severe infection, but the total daily dose should not exceed 4g. Children: 20-40mg/kg per day, divided into 3 doses. The dose can be doubled for patients with severe infection, but the total daily dose should not exceed 1g.

1. Common gastrointestinal reactions: soft stools, diarrhea, stomach discomfort, loss of appetite, nausea, vomiting, heating, etc. 2. Serum sickness-like reactions are more common than other antibiotics, especially in children, with typical symptoms including skin reactions and joint pain. 3. Allergic reactions: rash, urticaria, eosinophilia, vulvar itching, etc. 4. Others: mild increase in serum aminotransferase, urea nitrogen and creatinine, proteinuria, tubular urine, etc.

1. People who are allergic to this product and other cephalosporins; 2. Pregnant and lactating women should use with caution.

Precautions for children: The safety of the drug for newborns has not yet been determined. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. Precautions for the elderly: Elderly patients should adjust the dosage or medication interval according to their renal function under the guidance of a physician.

1. Furosemide, ethacrynic acid, bumetanide and other strong diuretics, carmustine, streptozocin and other antineoplastic drugs and aminoglycoside antibiotics and other nephrotoxic drugs combined with this product may increase nephrotoxicity. 2. Clavulanic acid can enhance the antibacterial activity of this product against certain Gram-negative bacteria that are resistant to this product due to the production of β-lactamase. 3. Oral administration of probenecid can delay the excretion of this product.

Keep away from light, seal tightly, and store in a cool, dark and dry place.

Calculated as C15H14ClN3O4S 0.25g

24 months

Chengdu Brilliant Pharmaceutical Co., Ltd.

• Founded in:

  1995-10-10

• Address:

  No. 263, Hexiang 3rd Street, Chengdu Hi-tech Zone

• Tax NO.:

  91510100633104205M

• Registered Funds:

  450 million yuan

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