Pamidronate Disodium Injection

This drug is an inhibitor of osteoclast osteolysis. It binds to hydroxyapatite crystals and inhibits the formation and dissolution of these crystals in vitro. The inhibition of osteoclast osteolysis in vivo is at least partly due to the attachment of these substances to the mineral bone matrix. This drug can be firmly adsorbed on the surface of trabeculae to form a protective film that prevents osteoclast precursor cells from adsorbing to bones and subsequently being transformed into mature osteoclasts. In most patients with hypercalcemia, this drug improves glomerular filtration rate and reduces serum creatinine levels by lowering serum calcium levels.

The chemical name of this product is disodium aminopropyl diphosphate, which is disodium-3-amino-hydroxypropyl-1,1-diphosphate pentahydrate. It also contains mannitol as an excipient.

This product is a colorless clear liquid.

Hypercalcemia and bone destruction and dissolution caused by malignant tumors and their bone metastases, eliminate pain, improve exercise ability, reduce pathological fractures, and reduce patients' requirements for radiotherapy. It can delay the development of osteolytic lesions, but has no effect on related complications (such as fractures and mortality). Bone lesions of Paget's disease and osteoporosis caused by various reasons

The general dosage for adults and elderly patients is 30-90 mg added to 250-500 mL of 0.9% saline or 5% glucose, and intravenously dripped for more than 1-4 hours. The total amount of treatment for a course of treatment depends on the patient's serum calcium level before treatment.

Sometimes transient flu-like symptoms occur, usually 3-24 hours after infusion, lasting 24 hours, and rarely reoccur when infused again. In addition, fever, chills, headache, muscle aches, gastrointestinal reactions such as anorexia, abdominal pain, constipation or diarrhea may also occur. Occasionally, allergic reactions and local reactions at the intravenous infusion site may occur. Lymphocytopenia, thrombocytopenia and hypocalcemia may occur.

Allergic to this drug or other bisphosphonates.

Precautions for children: Generally not used, may affect bone growth. Precautions for pregnancy and lactation: Pregnant women should weigh the pros and cons of medication, the drug can enter breast milk, so lactating women should use it with caution. Precautions for the elderly: Appropriately reduce the dosage.

Not yet clear.

Store away from moisture; the prepared solution remains stable at room temperature for 24 hours.

5 ml: 15 mg

24 months

Zhejiang Jinhua Aotuokang Pharmaceutical Group Inc. Co.

• Founded in:

  1994-02-21

• Address:

  Dingye New Village, Zhejiang Province

• Tax NO.:

  91330000147304738B

• Registered Funds:

  90 million yuan

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