Urapidil sustained-release capsules
Function and Efficacy
Urapidil is a highly selective α1 receptor blocker with both peripheral and central effects. The peripheral vasodilator effect is mainly to block postsynaptic α1 receptors, which significantly reduces peripheral resistance. At the same time, it also has a moderate vasoconstrictor effect of blocking catecholamines. The central effect is to reduce blood pressure by stimulating serotonin-1A receptors and reducing the sympathetic feedback regulation of the medullary cardiovascular center. At the same time, it can also improve various hemodynamic indicators by reducing the side effect of reflex heart rate acceleration.
Ingredients
6-[[3-[4-(2-methylaminophenyl)-1-piperazinyl]-propyl]-amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracilIngredients |
Urapidil is a highly selective α1 receptor blocker with both peripheral and central effects. The peripheral vasodilator effect is mainly to block postsynaptic α1 receptors, which significantly reduces peripheral resistance. At the same time, it also has a moderate vasoconstrictor effect of blocking catecholamines. The central effect is to reduce blood pressure by stimulating serotonin-1A receptors and reducing the sympathetic feedback regulation of the medullary cardiovascular center. At the same time, it can also improve various hemodynamic indicators by reducing the side effect of reflex heart rate acceleration. More |
34661-75-1 | 9 |
Appearance
This product is a capsule, and the contents are off-white to slightly yellow pellets.
Indication
This product is mainly used for essential hypertension, renal hypertension, and hypertension caused by pheochromocytoma.
Usage and Dosage
Adults usually start taking urapidil at 30 mg/day. If the effect is not obvious, the dose can be gradually increased to 60 mg or 120 mg per day over 1 to 2 weeks, taken orally in two doses. The dose can be increased or decreased appropriately based on age and symptoms.
Adverse Reactions
Symptoms may include headache, dizziness, nausea, vomiting, fatigue, palpitations, arrhythmia, itching and insomnia. If the drug is overdose or the dose is increased too quickly in the initial stage of medication, it may cause dizziness, orthostatic hypotension, collapse and fatigue. Symptomatic treatment should be given if necessary.
Precautions
1. People who are allergic to this product. 2. Pregnant and lactating women.
Special Population Medication
Precautions during pregnancy and lactation: This product is contraindicated for pregnant and lactating women
Storage
Store at room temperature in a sealed, dry place. The validity period is tentatively 18 months.
Packaging Specification
30mg
Manufacturer
HUA-YU (WUXI) Pharmaceutical Co., Ltd.
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Founded in:
1993-01-19 -
Address:
2nd Floor, Building 7, Phase II, Biomedical R&D Service Outsourcing Zone, No. 138 Meiliang Road, Mashan, Wuxi -
Tax NO.:
91320200607912858J -
Registered Funds:
$20 million -
Website:
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Email: