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Ornidazole Sodium Chloride Injection

Function and Efficacy

This product is a nitroimidazole derivative. Its mechanism of antimicrobial effect may be through the nitro group in its molecule, which is reduced to amino group in an anaerobic environment or through the formation of free radicals, which interact with cell components and lead to the death of microorganisms.

Ingredients

Ornidazole and sodium chloride.

Name Description Content CAS NO. Manufacturer
OrnidazoleIngredients

Through the nitro group in its molecule, it is reduced to amino group in an anaerobic environment or through the formation of free radicals, which interact with cell components and cause the death of microorganisms.

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16773-42-5 19
Sodium chlorideExcipients

This product is a nitroimidazole derivative. Its mechanism of antimicrobial effect may be through the nitro group in its molecule, which is reduced to amino group in an anaerobic environment or through the formation of free radicals, which interact with cell components and lead to the death of microorganisms.

More
7647-14-5 43

Appearance

This product is a colorless to slightly yellow clear liquid.

Indication

1. Used to treat various infectious diseases caused by sensitive anaerobic bacteria such as Bacteroides fragilis, Bacteroides dissimilar, Bacteroides ovale, Bacteroides thetaiotaomicron, Bacteroides vulgaris, Clostridium, Eubacterium, Peptococcus and Peptostreptococcus, Helicobacter pylori, Bacteroides melaninus, Fusobacterium, CO2-phagocytosis, Bacteroides gingivalis, etc., including: 1) Abdominal infection: peritonitis, intra-abdominal abscess, liver abscess, etc.; 2) Pelvic infection: endometritis, myometritis, fallopian tube or ovarian abscess, pelvic soft tissue infection, Haemophilus vaginitis, etc.; 3) Oral infection: periodontitis, apical periodontitis, pericoronitis, acute ulcerative gingivitis, etc.; 4) Surgical infection: wound infection, epidermal abscess, bedsore ulcer infection, cellulitis, gas gangrene, etc.; 5) Brain infection: meningitis, brain abscess;

Usage and Dosage

Intravenous drip, each bottle (100ml, concentration of 5mg/ml) drip time is not less than 30 minutes, dosage: 1. Prevention of infection caused by anaerobic bacteria: 1g of ornidazole is dripped once before surgery. 2. Treatment of infection caused by anaerobic bacteria: The first dose of intravenous drip is 0.5-1g, and then 0.5g is dripped every 12 hours for 5-10 days; children are dripped every 12 hours at a dose of 10mg/kg. For infection caused by anaerobic bacteria, if the patient's symptoms improve, it is recommended to switch to oral preparations. 3. Treatment of severe amoebic dysentery or amoebic abscess, the initial dose is 0.5-1g, and then 0.5g is dripped every 12 hours for 3-6 days. Children are dripped daily at a dose of 20-30mg/kg.

Adverse Reactions

This product is generally well tolerated. The following reactions may occur during medication: 1. Digestive system: including mild stomach discomfort, nausea, bad breath, etc.; 2. Nervous system: including dizziness, drowsiness, vertigo, etc.; 3. Allergic reactions: such as rash, itching, etc.; 4. Others: leukopenia, etc.

Precautions

1. It is contraindicated for patients who are allergic to nitroimidazole drugs; 2. It is contraindicated for patients with brain and spinal cord lesions and epilepsy. 3. It is contraindicated for patients with organ sclerosis, low hematopoietic function and chronic alcoholism.

Special Population Medication

Precautions for children: Use with caution in children. It is not recommended for children under 3 years old. Precautions for pregnancy and lactation: Use with caution in early pregnancy (first three months of pregnancy) and lactating women. Precautions for the elderly: Use the same medication as adults.

Drug Interactions

1. Compared with other nitroimidazole drugs, this product has no inhibitory effect on acetaldehyde dehydrogenase. 2. Ornidazole can inhibit the metabolism of the anticoagulant warfarin, prolong its half-life, and enhance the efficacy of the anticoagulant. When used with warfarin, the prothrombin time should be observed and the dosage should be adjusted.

Storage

Keep away from light and store in sealed container.

Packaging Specification

100ml: Ornidazole 0.25g and sodium chloride 0.825g

Validity Period

18 months

Manufacturer

Shaanxi Jinyu Pharmaceutical Co., Ltd.

  • Founded in:

    1998-09-02
  • Address:

    18th Floor, Eyang International Building, No. 27 Keji Road, High-tech Zone, Xi'an, Shaanxi Province
  • Tax NO.:

    91610000710075752Y
  • Registered Funds:

    35 million yuan
  • Email:

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