Naproxen Sodium Tablets

Naproxen has dose-dependent anti-inflammatory, analgesic and antipyretic effects. The intensity of the anti-inflammatory effect is about 11 times that of the same dose of phenylbutazone, and the analgesic and antipyretic effects are 7 and 22 times that of aspirin. The anti-inflammatory, analgesic and antipyretic effects are equivalent to indomethacin. The mechanism of action of naproxen is that it inhibits COX activity and thus inhibits PG synthesis, but its selective inhibition of COX2 is stronger, so it has a strong anti-inflammatory effect and less gastrointestinal adverse reactions.

Main ingredient: Naproxen sodium. Molecular formula: C14H13NaO3 Molecular weight: 252.25

This product is a capsule containing white powder.

This product is a non-steroidal anti-inflammatory drug. It is suitable for relieving various mild to moderate pains, such as pain after tooth extraction and other surgeries, primary dysmenorrhea and headaches. It is also suitable for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendinitis, bursitis and acute gouty arthritis. It can relieve the pain, swelling and limited activity of arthritis. Compared with aspirin and indomethacin, the effect of symptom relief is similar, but the incidence and severity of adverse reactions of the gastrointestinal tract and nervous system are lower.

Common oral dose for adults: 1. Anti-rheumatic, 0.25g~0.5g at a time, once in the morning and evening, or 0.25g in the morning and 0.5g at night. 2. Analgesic, 0.5g for the first time, 0.25g each time thereafter, once every 6-8 hours if necessary. 3. For acute attack of gouty arthritis, 0.7g for the first time, 0.25g each time thereafter, once every 8 hours, until the acute attack stops. 4. Dysmenorrhea, 0.5g for the first time, 0.25g each time thereafter if necessary, once every 6-8 hours, until the acute attack stops.

1. Skin itching, shortness of breath, dyspnea, asthma, tinnitus, lower limb edema, stomach burning sensation, indigestion, stomach pain or discomfort, constipation, dizziness, drowsiness, headache, nausea and vomiting, etc., with an incidence of 3% to 9%. 2. Blurred vision or visual impairment, hearing loss, diarrhea, oral irritation or pain, palpitations and sweating, etc., with an incidence of 1% to 3%. 3. Gastrointestinal bleeding, kidney damage (allergic nephritis, pain disease, renal papillary necrosis and renal failure, etc.), urticaria, allergic rash, depression, muscle weakness, bleeding or granulocytopenia and liver damage, etc. are less common, with an incidence of 1% to 3%.

It is prohibited for people who are allergic to aspirin, and should be used with caution by those with peptic ulcer or history of peptic ulcer.

1 When drinking alcohol or taking it with other anti-inflammatory drugs, gastrointestinal adverse reactions increase and there is a risk of ulcers. 2 When used with anticoagulants such as heparin and dicoumarol, the bleeding time is prolonged, bleeding tendency may occur, and there is a possibility of causing gastrointestinal ulcers. 3 When used with aspirin or other salicylic acid preparations, it does not enhance symptom relief, but increases gastrointestinal adverse reactions. 4 This product can reduce the sodium excretion and antihypertensive effects of furosemide. 5 This product can inhibit the excretion of lithium in the urine, thereby increasing the blood concentration of lithium. 6 When used with probenecid, the blood concentration of this product increases, t1/2 is prolonged, and the efficacy can be increased, but the toxicity reaction is also increased accordingly, so it has no practical value and should not be recommended in clinical practice.

Seal and store in a cool place.

0.275g (equivalent to 0.25g of naproxen)