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Naproxen sodium

Naproxen sodium structure

CAS No:
26159-34-2
Formula:
C14H14O3.Na
Chemical Name:
Naproxen sodium
Synonyms:
2-Naphthaleneacetic acid,6-methoxy-α-methyl-,sodium salt (1:1),(αS)-;2-Naphthaleneacetic acid,6-methoxy-α-methyl-,sodium salt,L-(-)-;2-Naphthaleneacetic acid,6-methoxy-α-methyl-,sodium salt,(S)-;2-Naphthaleneacetic acid,6-methoxy-α-methyl-,sodium salt,(αS)-;Naproxen sodium;Sodium naproxen;Naprosyn sodium;Sodium naprosyn;Sodium (+)-6-methoxy-2-naphthalenepropionate;Sodium d-2-(6-methoxy-2-naphthyl)propionate;Apranax;Aleve;Xenobid;Anaprox;Anaprox DS;Naprelan;Flanax Forte;Naprogesic;Apraxin;Uniflam;Lefaine;Sutolin;Duk-F;Agilxen;Synflex;Apronax;Licorax;Flanax;Anax;Dafloxen;Narocin;Gynestrel;Axer;Miranax;RS 3560;Primeral;(2S)-2-(6-Methoxy-2-naphthyl)propanoic acid sodium salt;Aflaxen;Synflex Forte;Sunprox;(+)-(S)-Naproxen sodium salt
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

White Powder

Naproxen sodium is an organic sodium salt consisting of equimolar amounts of naproxen(1-) anions and sodium anions. It has a role as a non-narcotic analgesic, a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor, an antipyretic and a non-steroidal anti-inflammatory drug. It contains a naproxen(1-).|Naproxen Sodium is the sodium salt form of naproxen, a member of the arylacetic acid group of non-steroidal anti-inflammatory drugs (NSAIDs) with anti-inflammatory analgesic and antipyretic properties. Naproxen sodium reversibly and competitively inhibits cyclooxygenases (COX), thereby blocking the conversion of arachidonic acid to pro-inflammatory prostaglandins. This inhibits the formation of prostaglandins that are involved in pain, inflammation and fever.|An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.

Naproxen sodium Basic Attributes

Molecular Weight：

252.24

Exact Mass：

252.076

EC Number：

247-486-2

UNII：

9TN87S3A3C

DSSTox ID：

DTXSID7045576

NCI Thesaurus Code：

C48006

HScode：

2918992090

Characteristics

PSA：

49.4

XLogP3：

1.70180

Appearance：

white powder

Melting Point：

244-246 °C

Boiling Point：

403.9ºC at 760 mmHg

Flash Point：

154.5ºC

Water Solubility：

Soluble in water up to 100mg/mlSoluble in methanol and chloroform. Slightly soluble in ether. Insoluble in water.

Storage Conditions：

Commercially available naproxen and naproxen sodium conventional tablets and naproxen delayed-release (enteric-coated) tablets should be stored in well-closed containers at 15 - 30 deg C; the containers for the delayed-release tablets also should be light resistant. Extended-release naproxen sodium tablets should be stored in well-closed containers at 20 - 25 deg C. Naproxen oral suspension should be stored in light-resistant containers at 15 - 30 deg C, and temperatures exceeding 40 deg C shoul

Vapor Pressure：

1.89X10-6 mm Hg at 25 deg C (est)

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 3249

wgk germany：

hazard class code：

R22

safety instructions：

53-45

RTECS Number：

QJ1047000

Marks：

Xn,T

Precautionary statement(s)：

P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Danger|H302 (61.48%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 136 companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)|Agents that increase uric acid excretion by the kidney (URICOSURIC AGENTS), decrease uric acid production (antihyperuricemics), or alleviate the pain and inflammation of acute attacks of gout. (See all compounds classified as Gout Suppressants.)

MeSH Entry Terms：

Aleve

Naproxen sodium Use and Manufacturing

Uses

Used as anti-inflammatory analgesic Naproxen (Aleve, Anaprox) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:252.24
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:252.07623855
Monoisotopic Mass:252.07623855
Topological Polar Surface Area:49.4
Heavy Atom Count:18
Complexity:282
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is a non-steroidal anti-inflammatory drug that can inhibit the synthesis of prostaglandins and exert anti-inflammatory and analgesic effects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Naproxen Sodium Tablets
Ingredients	Main ingredient: Naproxen sodium. Molecular formula: C14H13NaO3 Molecular weight: 252.25
Indication	1 Drinking alcohol or using it with other anti-inflammatory analgesics can increase gastrointestinal adverse reactions and the risk of ulcer attacks. 2 When used with anticoagulants such as heparin and dicoumarol, the bleeding time is prolonged, bleeding tendency may occur, and there is a possibility of causing gastrointestinal ulcers. 3 This product can reduce the sodium excretion and antihypertensive effects of furosemide. 4 This product can inhibit the excretion of potassium and increase the blood concentration of potassium. 5 When used with probenecid, the blood concentration of this product increases, the half-life is prolonged, the efficacy is increased, but the adverse reactions also increase accordingly. 6 If you are taking other medicines, please consult a doctor or pharmacist before using this product.
Specifications	0.275g (equivalent to 250mg of naproxen)
Manufacturer	Bayer Healthcare Company Ltd.

Naproxen Sodium for Injection
Ingredients	The main ingredient of this product is: naproxen sodium.
Specifications	0.275g (calculated as naproxen sodium)
Manufacturer	Hainan Hualon Pharmaceutical Co., Ltd.

Naproxen Sodium
Manufacturer	Zhejiang Tianxin Pharmaceutical Co., Ltd.

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Registered Holders

HETERO LABS LTD

United States
Active
APITORIA PHARMA PRIVATE LTD

United States
Active
DIVIS LABORATORIES LTD

United States
Active

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