Hydroxyurea tablets
Function and Efficacy
It is a nucleoside diphosphate reductase inhibitor that can prevent nucleotides from being reduced to deoxynucleotides, interfere with the biosynthesis of purine and pyrimidine bases, selectively inhibit DNA synthesis, and have no blocking effect on RNA and protein synthesis. It is a cycle-specific drug, and is sensitive to S-phase cells.
Ingredients
The main ingredient of this product is hydroxyurea.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| HydroxyureaIngredients |
It is a nucleoside diphosphate reductase inhibitor that can prevent nucleotides from being reduced to deoxynucleotides, interfere with the biosynthesis of purine and pyrimidine bases, selectively inhibit DNA synthesis, and have no blocking effect on RNA and protein synthesis. It is a cycle-specific drug, and is sensitive to S-phase cells. More |
127-07-1 | 14 |
Appearance
This product is white tablets.
Indication
1. It is effective for chronic myeloid leukemia (CML) and can be used for CML resistant to Myleranine; 2. It has certain effects on melanoma, renal cancer, head and neck cancer, and is effective in combination with radiotherapy for head and neck and cervical squamous cell carcinoma.
Usage and Dosage
Orally administered, CML is 20 to 60 mg/kg daily, twice a week, with a 6-week course of treatment; head and neck cancer, cervical squamous cell carcinoma, etc. are 80 mg/kg each time, once every three days, and must be combined with radiotherapy.
Adverse Reactions
1. Myelosuppression is a dose-limiting toxicity that can cause leukopenia and thrombocytopenia, which can be restored 1 to 2 weeks after discontinuation of the drug. 2. Gastrointestinal reactions sometimes occur, and there are reports of testicular atrophy and teratogenicity. 3. Central nervous system symptoms and alopecia occasionally occur, and there are also reports of drug-induced fever caused by this drug, which may recur when the drug is administered repeatedly.
Precautions
It is contraindicated for use in patients with chickenpox, herpes zoster and various serious infections.
Drug Interactions
It may reduce the conversion of 5-Fu into active metabolites (Fd-UMP), so the combination of the two should be used with caution; this product has an inhibitory effect on the central nervous system, so barbiturates, diazepams, anesthetics, etc. should be used with caution; this product may increase the concentration of uric acid in the patient's blood, so when used in combination with allopurinol, colchicine, probenecid, etc. to treat gout, the dosage of the above drugs must be adjusted. This product combined with allopurinol can prevent and reverse the hyperuricemia caused by it, and there is no cross-resistance with alkylating agents.
Storage
Keep away from light and store in sealed container.
Packaging Specification
0.25g
Manufacturer
Anguo Yadong Biological Pharmaceutical Co., Ltd.
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Founded in:
2022-12-28 -
Address:
No. 1 Yifeng Road, Anguo City, Baoding City, Hebei Province -
Tax NO.:
91130683MAC5U0752B -
Registered Funds:
20 million yuan -
Email: