Indomethacin Capsules

This product is a non-steroidal anti-inflammatory drug with anti-inflammatory, antipyretic and analgesic effects. Its mechanism of action is to reduce the synthesis of prostaglandins by inhibiting cyclooxygenase. It stops the formation of pain nerve impulses in inflammatory tissues and inhibits inflammatory reactions, including inhibiting the chemotaxis of leukocytes and the release of lysosomal enzymes. As for the antipyretic effect, it acts on the hypothalamic temperature regulation center, causing peripheral vasodilation and sweating, which increases heat dissipation. This central antipyretic effect may also be related to the inhibition of prostaglandin synthesis in the hypothalamus.

The chemical name of this product is 2-methyl-1-(4-chlorobenzoyl)-5-methoxy-1H-indole-3-acetic acid. Molecular formula: C19H16CINO4 Molecular weight: 357.79

This product is white tablets.

Used for: 1 Arthritis, to relieve pain and swelling. 2 Soft tissue injury and inflammation; 3 Antipyretic; 4 Others: used to treat migraine, dysmenorrhea, postoperative pain, post-traumatic pain, etc.

Oral 1 Common dosage for adults: ① Anti-rheumatic, initial dose 25-50 mg once, 2-3 times a day, the maximum daily dose should not exceed 150 mg. ② Analgesia, first dose 25-50 mg once, followed by 25 mg, 3 times a day, until the pain is relieved, you can stop the drug; ③ Antipyretic, 6.25-12.5 mg once, no more than 3 times a day 2 Common dosage for children: 1.5-2.5 mg/kg per day, divided into 3-4 times. Reduce to the lowest dose after it is effective.

This product has many adverse reactions. 1. Gastrointestinal tract: symptoms such as indigestion, stomach pain, burning sensation in the stomach, nausea and acid reflux, ulcers, gastric bleeding and gastric perforation; 2. Nervous system: headache, dizziness, anxiety and insomnia, severe cases may have mental and behavioral disorders or convulsions; 3. Kidney: hematuria, edema, renal insufficiency, more common in the elderly; 4. Various types of rashes, the most serious of which is bullous erythema multiforme (Stevens-Johnson syndrome); 5. The hematopoietic system is suppressed, resulting in aplastic anemia, leukopenia or thrombocytopenia, etc.; 6. Allergic reactions, asthma, angioedema and shock, etc.

It is contraindicated for patients with active ulcer disease, ulcerative colitis or a history of the disease, epilepsy, Parkinson's disease, mental illness, liver and kidney dysfunction, allergic to this product or to aspirin or other non-steroidal anti-inflammatory drugs, angioedema or bronchial asthma.

Precautions for children: Children under 14 years old are generally not suitable for this drug. If it must be used, it should be closely observed to prevent the occurrence of serious adverse reactions. Precautions for pregnancy and lactation: 1. This product can cause fetal ductus arteriosus occlusion and persistent pulmonary hypertension when used in the last 3 months of pregnancy. It is contraindicated for pregnant women. 2. This product can be excreted from breast milk and can cause toxic and side effects to infants. It is contraindicated for lactating women. Precautions for the elderly: Elderly patients are prone to renal toxicity and should be used with caution.

1. Long-term use with acetaminophen can increase renal toxicity, and the incidence of gastrointestinal ulcers increases when used with other non-steroidal anti-inflammatory drugs; 2. When used with aspirin or other salicylates, it does not enhance the therapeutic effect, but gastrointestinal adverse reactions increase significantly. Because the platelet aggregation inhibition effect is enhanced, the bleeding tendency can be increased; 3. Drinking alcohol or using it with corticosteroids and adrenocorticotropic hormone can increase the risk of gastrointestinal ulcers or bleeding; 4. When used with digitalis drugs, this product can increase the blood concentration of digitalis (due to inhibition of clearance from the kidneys) and increase toxicity, so the dose of digitalis needs to be adjusted; 5. When used with heparin, oral anticoagulants and thrombolytics, this product competes with them for protein binding, which enhances the anticoagulant effect. At the same time, this product has the effect of inhibiting platelet aggregation, so there is a potential risk of increasing bleeding; 6. This product can enhance the hypoglycemic effect when used in combination with insulin or oral hypoglycemic drugs, and the dosage of hypoglycemic drugs must be adjusted; 7. When used with furosemide, it can weaken the latter's sodium excretion and antihypertensive effects, and the reason may be due to the inhibition of prostaglandin synthesis in the kidney. This product also has the effect of preventing the enhancement of plasma renin activity by sefolosha, bumetanide and indapamide. This point should be noted when evaluating the significance of plasma renin activity in hypertensive patients; 8. When used in combination with triamterene, it can cause renal dysfunction (decreased creatinine clearance, azotemia); 9. When this product is used in combination with nifedipine or verapamil, it can increase the blood concentration of the latter two, thereby increasing toxicity; 10. Probenecid can reduce the clearance of this product from the kidney and bile, increase blood concentration, and increase toxicity. When used in combination, the dosage must be reduced; 11. When used in combination with colchicine and sulfinpyrazone It may increase the risk of gastrointestinal ulcers and bleeding; 12 When used with lithium salts, it can reduce the excretion of lithium in the urine, increase the blood concentration and increase the toxicity; 13 This product can increase the blood concentration of methotrexate and prolong the time of high blood concentration. If patients who are using this product need to take medium or large doses of methotrexate, they should stop taking this product 24-48 hours in advance to avoid increasing its toxicity; 14 When used with the antiviral drug zidovudine, the latter's clearance rate can be reduced and its toxicity increased. At the same time, the toxicity of this product is also increased, so the combined use should be avoided.

Keep away from light and store in sealed container.

25mg

24 months

Hebei Yongfeng Pharmaceutical Co., Ltd.

• Founded in:

  2004-12-23

• Address:

  Xiangyang Street, East of Wuji County, Shijiazhuang City, Hebei Province

• Tax NO.:

  911301307698214303

• Registered Funds:

  60 million yuan

• Email:

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