Indomethacin sustained-release tablets

This product has anti-inflammatory, antipyretic and analgesic effects. Its mechanism of action is to reduce the synthesis of prostaglandins by inhibiting cyclooxygenase. It stops the formation of pain nerve impulses in inflammatory tissues and inhibits inflammatory reactions, including inhibiting the chemotaxis of leukocytes and the release of lysosomal enzymes. As for the antipyretic effect, it acts on the hypothalamic temperature regulation center, causing peripheral vasodilation and sweating, which increases heat dissipation. This central antipyretic effect may also be related to the inhibition of prostaglandin synthesis in the hypothalamus.

The main ingredient of this product is indomethacin, whose chemical name is 2-methyl-1-(4-chlorobenzoyl)-5-methoxy-1H-indole-3-acetic acid.

It is suitable for relieving symptoms during acute attacks of rheumatoid arthritis, rheumatic arthritis, ankylosing spondylitis, osteoarthritis and gout.

Oral administration. 75 mg once a day; or 75 mg twice a day; or as directed by a doctor. Rheumatoid patients should take 50-75 mg once a day at the beginning, and gradually increase to 25-50 mg after one week to achieve satisfactory results. The maximum daily dose should not exceed 200 mg. For acute conditions, such as gouty arthritis, take 100 mg once a day at the beginning, and then 75 mg twice a day to control pain, then quickly reduce the dose and stop taking the medicine.

This product has many adverse reactions. 1. Gastrointestinal tract: symptoms such as indigestion, stomach pain, burning sensation in the stomach, nausea and acid reflux, ulcers, gastric bleeding and gastric perforation; 2. Nervous system: headache, dizziness, anxiety and insomnia, and in severe cases, mental and behavioral disorders or convulsions; 3. Kidney: hematuria, edema, renal insufficiency, more common in the elderly; 4. Various types of rashes, the most serious of which is bullous erythema multiforme (Stevens-Johnson syndrome); 5. The hematopoietic system is suppressed, resulting in aplastic anemia, leukopenia or thrombocytopenia, etc.; 6. Allergic reactions

It is contraindicated in patients with renal insufficiency, active gastric and duodenal ulcers.

1 Long-term co-use with acetaminophen can increase renal toxicity, and the incidence of gastrointestinal ulcers increases when used with other non-steroidal anti-inflammatory drugs. 2 When used with aspirin or other salicylates, it does not enhance the therapeutic effect, but the gastrointestinal adverse reactions increase significantly. Due to the enhanced inhibition of platelet aggregation, the bleeding tendency may increase. 3 Drinking alcohol or using it with corticosteroids and adrenocorticotropic hormone may increase the risk of gastrointestinal ulcers or bleeding. 4 When used with digitalis drugs, this product can increase the blood concentration of digitalis (due to inhibiting clearance from the kidneys) and increase toxicity, so the dose of digitalis needs to be adjusted. 5 Use with heparin, oral anticoagulants and

Keep away from light and store in sealed container.

75 mg

JiangSu Ruinian Qianjin Pharmaceutical Co., Ltd.

• Founded in:

  1979-11-20

• Address:

  Chuanbu Village, Dingshu Town, Yixing City

• Tax NO.:

  91320282142846159Q

• Registered Funds:

  31 million yuan

• Email:

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