Compound Lophatherum gracile tablets Ⅰ
Function and Efficacy
This product was administered orally to experimental dogs with renal hypertension at a dose of 0.2g/kg, which significantly reduced blood pressure from 190/142mmHg to 153/98mmHg 2 hours after oral administration. This product was administered orally to dogs and cats at 0.2g/kg and 0.4g/kg, which slowed the heart rate 20 minutes later and lasted for 5 hours. This product was administered orally to rats at 0.3g/kg and 0.6g/kg, which significantly counteracted arrhythmias caused by aconitine, calcium chloride and coronary artery ligation, and its anti-arrhythmic mechanism may be related to the effect on calcium ion influx. This product was administered orally to mice at 0.6g/kg and 1.2g/kg, which reduced spontaneous activity in mice and had a synergistic effect with sodium pentobarbital, increasing the number of times the righting reflex disappeared in mice.
Ingredients
This product is a compound preparation, and its components per 1000 tablets include: 218.5g of Apocynum venetum leaves, 171.0g of wild chrysanthemum, 184.2g of Stephania tetrandra, 15.0g of magnesium trisilicate, 1.6g of hydralazine sulfate, 1.6g of hydrochlorothiazide, 1.05g of promethazine hydrochloride, 0.5g of vitamin B1, 0.5g of vitamin B6, and 0.25g of calcium pantothenate.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Magnesium trisilicateIngredients |
Antihypertensive, antiarrhythmic, sedative More |
14987-04-3 | 11 | |
| Dihydralazine sulphateIngredients |
Lowers blood pressure More |
7327-87-9 | 9 | |
| HydrochlorothiazideIngredients |
Lowers blood pressure More |
58-93-5 | 56 | |
| Promethazine hydrochlorideIngredients |
Sedation More |
58-33-3 | 29 | |
| Thiamine chlorideIngredients |
No specific pharmacological effects mentioned More |
59-43-8 | 9 | |
| Vitamin B6Ingredients |
No specific pharmacological effects mentioned More |
8059-24-3 | 13 | |
| Calcium D-PantothenateIngredients |
No specific pharmacological effects mentioned More |
137-08-6 | 8 |
Appearance
This product is a sugar-coated tablet. After removing the sugar coating, it is gray-brown, has a slight fragrance, and tastes bitter and astringent.
Indication
Lowers blood pressure, used for hypertension.
Usage and Dosage
Oral administration. 2 tablets at a time, 3 times a day. Maintenance dose: 2 tablets a day.
Adverse Reactions
No adverse reactions have been reported.
Precautions
It is contraindicated for those who are allergic to this product.
Special Population Medication
Precautions for children: Reduce the dosage or follow the doctor's advice. Precautions for pregnancy and lactation: This product is not the first choice for pregnant and lactating women with hypertension. Precautions for the elderly: Not yet clear.
Drug Interactions
Not yet clear.
Storage
Keep away from light and store in a sealed container.
Packaging Specification
Compound
Validity Period
24 months.
Manufacturer
Jiangxi Juwang Pharmaceutical Co., Ltd.
-
Founded in:
2000-12-28 -
Address:
Fuxi Industrial Park, Nanfeng County, Fuzhou City, Jiangxi Province -
Tax NO.:
9136102372391675XE -
Registered Funds:
43.98 million yuan -
Website:
-
Email: