Trimetazidine Hydrochloride Tablets
Function and Efficacy
Anti-anginal drugs. It has the effect of antagonizing adrenaline, norepinephrine and vasopressin, can reduce vascular resistance, increase coronary and circulatory blood flow, promote myocardial metabolism and myocardial energy production. At the same time, it can reduce myocardial oxygen consumption, thereby improving the balance of myocardial oxygen supply and demand. It can also increase tolerance to cardiac glycosides. Controlled trials in patients with angina pectoris showed: 1. This drug can increase the exercise test tolerance of patients with angina pectoris, delay exercise-induced myocardial ischemia from d15 of treatment, reduce ischemia, but does not cause hemodynamic changes. 2. Limiting rapid blood pressure fluctuations does not cause significant changes in heart rate, and significantly reduces the frequency of angina attacks. 3. The dosage of nitroglycerin is significantly reduced. Mechanism of action of trimetazidine: The effect on ischemic myocardium may be a direct cell protective effect. By preserving the energy metabolism in ischemic cells and preventing the decrease of intracellular ATP levels, it ensures the perfect function of ion pumps and normal transport of transmembrane sodium-potassium pumps while maintaining the stability of the intracellular environment, reduces intracellular acidosis, prevents the accumulation of sodium and calcium in myocardial cells, protects cell contractile function and limits cell lysis and endothelial damage caused by oxygen free radicals.
Ingredients
Ingredients: The active ingredient of this product is trimetazidine hydrochloride, its chemical name: 1-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride, molecular formula: C14H22N2O3.2HCL molecular weight: 339.3
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Trimetazidine dihydrochlorideIngredients |
Anti-angina drug. It has the effect of antagonizing adrenaline, norepinephrine and vasopressin, can reduce vascular resistance, increase coronary and circulatory blood flow, promote myocardial metabolism and myocardial energy production. At the same time, it can reduce myocardial oxygen consumption, thereby improving the balance of myocardial oxygen supply and demand. It can also increase tolerance to cardiac glycosides. By preserving the energy metabolism in ischemic cells and preventing the decrease of intracellular ATP levels, it ensures the perfect function of ion pumps and normal transmembrane sodium-potassium pump transport while maintaining the stability of the intracellular environment, reduces intracellular acidosis and prevents the accumulation of sodium and calcium in myocardial cells, protects cell contraction function and limits cell lysis and endothelial damage caused by oxygen free radicals. More |
13171-25-0 | 31 |
Appearance
This product is a film-coated tablet, which appears white after removing the film coating.
Indication
Preventive treatment of angina attacks and auxiliary symptomatic treatment of vertigo and tinnitus.
Usage and Dosage
Oral, 40-60 mg/24 hours; 2-3 times a day, 1 tablet each time, take with a glass of water during meals. All patients must take this medicine strictly according to the doctor's prescription.
Adverse Reactions
Very few patients experience gastrointestinal discomfort (nausea, vomiting).
Precautions
It is contraindicated for those who are allergic to any of the components of the drug. It is usually not recommended for use during breastfeeding (see [Use in Pregnant and Lactating Women]).
Special Population Medication
Precautions for children: The safety and effectiveness of the drug for children have not been determined. Precautions for pregnancy and lactation: 1. The effect of the drug on pregnancy cannot completely rule out the risk of teratogenicity of the drug. For safety reasons, the drug should be avoided during pregnancy. 2. The effect of the drug on lactation It is not clear whether the drug is secreted through breast milk. It is recommended to stop breastfeeding during treatment. Precautions for the elderly: See the content under other items or follow the doctor's advice.
Drug Interactions
To avoid possible interactions between different medicines, you must tell your doctor or pharmacist about other treatments you are taking.
Storage
Sealed, store in a dry place.
Packaging Specification
20mg
Validity Period
36 months.
Manufacturer
Beijing Foyou Pharma Co., Ltd.
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Founded in:
1999-02-03 -
Address:
No. 8 Guangyuan East Street, Tongzhou Industrial Development Zone, Tongzhou District, Beijing -
Tax NO.:
91110112700216160K -
Registered Funds:
480 million yuan -
Website:
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Email: