Trimebutine Maleate Sustained-Release Tablets
Function and Efficacy
After 0.58±0.15 hours after oral administration of 100mg trimebutine maleate by healthy adult males, the maximum concentration of trimebutine maleate in the blood reached 44±32ng/ml, and the half-life was 1.73±0.77 hours. This product is hydrolyzed in the body, and after N-position demethylation, it is excreted in the urine. The excretion rate of unchanged substances in urine for 24 hours is below 0.01%.
Ingredients
Trimebutine Maleate. Chemical name: (±)-3,4,5-Trimethoxybenzoic acid (2-dimethylamino-2-phenyl) butyl ester maleate Molecular weight: C22H29NO5·C4H4O4
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Trimebutine maleateIngredients |
After 0.58±0.15 hours after oral administration of 100mg trimebutine maleate by healthy adult males, the maximum concentration of trimebutine maleate in the blood reached 44±32ng/ml, and the half-life was 1.73±0.77 hours. This product is hydrolyzed in the body, and after N-position demethylation, it is excreted in the urine. The excretion rate of unchanged substances in urine for 24 hours is below 0.01%. More |
34140-59-5 | 12 |
Appearance
This product is a white film-coated tablet.
Indication
1. Improvement of symptoms such as loss of appetite, nausea, vomiting, belching, abdominal distension, abdominal borborygmus, abdominal pain, diarrhea and constipation caused by gastrointestinal motility disorders. 2. Irritable bowel syndrome. 3. Loss of appetite, nausea, vomiting, belching, abdominal distension, abdominal borborygmus, abdominal pain caused by gastrointestinal motility disorders.
Usage and Dosage
For adults, take orally, 0.1-0.2 g each time, 3 times a day. The dosage can be appropriately increased or decreased according to age and symptoms, or as directed by a doctor.
Adverse Reactions
This product has low toxicity, and the adverse reactions are few and mild. Occasionally: Gastrointestinal: diarrhea, bowel sounds, constipation, vomiting. Central nervous system: drowsiness, dizziness, headache, fatigue. Skin: rash, hot and cold sensation. Liver function changes: elevated transaminases. Others: thirst, numbness in the mouth, and tachycardia.
Precautions
Contraindicated in case of hypersensitivity to trimebutine maleate.
Special Population Medication
Precautions for children: Use with caution in children. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. Precautions for the elderly: Elderly people usually have weaker physiological functions and should pay attention to reducing the dosage.
Drug Interactions
Co-administration of proton pump inhibitors accelerates ulcer healing.
Storage
Keep away from light and store in sealed container.
Packaging Specification
0.3g
Validity Period
36 months
Manufacturer
Xinhe Yuansheng MEDICINE Co., Ltd.
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Founded in:
1989-10-20 -
Address:
No. 185, Liaocheng East Road, Gushi County -
Tax NO.:
91411525706758024M -
Registered Funds:
84 million yuan -
Website:
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Email: