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Trimebutine maleate

Trimebutine maleate structure

CAS No:
34140-59-5
Formula:
C22H29NO5.C4H4O4
Chemical Name:
Trimebutine maleate
Synonyms:
Benzoic acid,3,4,5-trimethoxy-,2-(dimethylamino)-2-phenylbutyl ester,(2Z)-2-butenedioate (1:1);Benzoic acid,3,4,5-trimethoxy-,β-(dimethylamino)-β-ethylphenethyl ester maleate (1:1);Benzoic acid,3,4,5-trimethoxy-,2-(dimethylamino)-2-phenylbutyl ester,(Z)-2-butenedioate (1:1);Trimebutine maleate;Debridat;Dromostat;TM 906;Spabucol;Cerekinon;Polibutin;Digerent;Foldox;Trimedat;Gast-Reg;39133-32-9
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

Description

Trimebutine maleate is a drug with antimuscarinic and weak mu opioid agonist effects.Target: Opioid ReceptorTrimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain [1]. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine, which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a

Trimebutine maleate is a trihydroxybenzoic acid.|Proposed spasmolytic with possible local anesthetic action used in gastrointestinal disorders.

Trimebutine maleate Basic Attributes

Molecular Weight：

503.54200

Exact Mass：

503.21600

EC Number：

251-845-9

UNII：

DKM38HXX5A|H4XZJ9GX7T

NSC Number：

758900

DSSTox ID：

DTXSID5046017

HScode：

2922199090

Characteristics

PSA：

131.83000

Density：

1.104g/cm3

Melting Point：

105-106 °C

Boiling Point：

457.9ºC at 760mmHg

Flash Point：

230.8ºC

Refractive Index：

1.610

Storage Conditions：

2-8ºC

Collision Cross Section：

198.7 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R34

safety instructions：

S26; S27; S36/37/39; S45

RTECS Number：

DI0360000

Marks：

Precautionary statement(s)：

P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (16.67%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 10 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)|Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion. (See all compounds classified as Gastrointestinal Agents.)

MeSH Entry Terms：

Debridat

Trimebutine maleate Use and Manufacturing

Opioid receptor agonist. Antispasmodic Used as an intermediate in organic synthesis; used to treat gastrointestinal spasm, it is trimebutine maleate pex.

Computed Properties

Molecular Weight:503.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:12
Exact Mass:503.21553163
Monoisotopic Mass:503.21553163
Topological Polar Surface Area:132
Heavy Atom Count:36
Complexity:585
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

1. Regulating gastric motility: it can reduce the amplitude of gastric autonomic motility, increase the frequency and amplitude of irregular weak motility, and make it tend to be regular; 2. Inducing propulsive motility of the digestive tract system: it can induce physiological propulsive motility of the digestive tract in the adult digestive system; 3. Improving gastric emptying function: it can improve the weakened or hyperactive gastric emptying function of patients with chronic gastritis; 4. Regulating intestinal motility: it can regulate the muscle tension of colon specimens and inhibit the hypermotility of the large intestine caused by allergic enteritis syndrome; 5. Regulating the lower esophageal sphincter pressure (LESP): it can reduce the increase in internal pressure caused by tetragastrin load, and at the same time, it can also recover the decrease in internal pressure caused by secretin; 6. Direct effect on digestive tract smooth muscle: it still has a direct effect on digestive tract smooth muscle under various conditions, and can non-competitively inhibit the contraction caused by acetylcholine; 7. Terminal antiemetic effect: it has a significant inhibitory effect on vomiting induced by copper sulfate.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

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Ingredients	trimebutinemaleate
Indication	Co-administration of proton pump inhibitors accelerates ulcer healing.
Specifications	0.2g
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Trimebutine Maleate
Manufacturer	Hainan Poly Pharm. Co., Ltd.

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Registered Holders

XINHE YUANSHENG MEDICINE CO.,LTD.

Japan
Active
EDMOND PHARMA S.r.l.

Japan
Active
PMC ISOCHEM

France
Active

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