Dipyridamole Tablets
Function and Efficacy
It has anti-thrombotic effect. Dipyridamole inhibits platelet aggregation, and high concentrations (50 mu; g/ml) can inhibit platelet release. The mechanism of action may be 1. Inhibition of erythrocyte uptake of adenosine, which is a platelet reaction inhibitor; 2. Inhibition of phosphodiesterase, which increases cyclic adenosine monophosphate (cAMP) in platelets; 3. Inhibition of thromboxane A2 (TXA2) formation, TXA2 is a strong agonist of platelet activity; 4. Enhancement of endogenous PGI2. Dipyridamole has a vasodilatory effect. Dogs given 0.5~4.0 mg/kg of dipyridamole by duodenum produced a dose-related decrease in systemic and coronary vascular resistance, a decrease in systemic blood pressure, and an increase in coronary blood flow. It takes effect 24 minutes after administration and lasts for about 3 hours. Similar effects were observed after intravenous injection of 0.025~2.0 mg/kg.
Ingredients
Dipyridamole. Molecular formula: C21H40N8O4 Molecular weight: 504.63
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| DipyridamoleIngredients |
It has anti-thrombotic effects. It inhibits platelet aggregation and release. The mechanism includes inhibiting the uptake of adenosine by red blood cells, inhibiting phosphodiesterase to increase cAMP in platelets, inhibiting the formation of thromboxane A2, and enhancing endogenous PGI2. It also has a vasodilating effect, which can reduce systemic circulation and coronary vascular resistance and increase coronary blood flow. More |
58-32-2 | 35 |
Appearance
This product is a sugar-coated tablet, which appears yellow after removing the sugar coating.
Indication
Used for thromboembolic diseases and ischemic heart disease.
Usage and Dosage
Oral administration: 25-50 mg each time, 3 times a day, before meals. Or as directed by a doctor.
Adverse Reactions
Adverse reactions are mild and short-lived at therapeutic doses, and most of the initial side effects disappear after long-term use. Common adverse reactions include dizziness, headache, vomiting, diarrhea, flushing, rash and itching, and rarely angina and liver dysfunction. Persistent or intolerable adverse reactions are rare and can be eliminated after discontinuation of the drug. In post-marketing experience reports, rare adverse reactions include laryngeal edema, fatigue, discomfort, myalgia, arthritis, nausea, dyspepsia, paresthesia, hepatitis, alopecia, cholelithiasis, palpitations and tachycardia.
Precautions
Contraindicated for allergy sufferers.
Special Population Medication
Precautions for children: The safety and efficacy of the drug for children under 12 years old have not been determined. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: Not yet clear.
Drug Interactions
Not yet clear.
Storage
Keep away from light and store in a sealed container.
Packaging Specification
25 mg
Validity Period
24 months.
Manufacturer
CSPC OUYI Pharmaceutical Co., Ltd.
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Founded in:
2001-03-29 -
Address:
No. 88, Yangzi Road, Shijiazhuang Economic and Technological Development Zone -
Tax NO.:
91130100601289268L -
Registered Funds:
298 million yuan -
Website:
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Email: