Aspirin enteric-coated tablets

This product can inhibit the synthesis of prostaglandins and has antipyretic and analgesic effects

Aspirin. Chemical name: 2-(acetoxy)benzoic acid, molecular formula: C9H8O4, molecular weight: 180.2

This product is an enteric-coated tablet, which appears white after removing the coating.

Inhibit platelet aggregation, prevent thrombosis, treat and prevent transient ischemic attack, cerebral thrombosis, coronary heart disease, myocardial infarction, migraine, artificial heart valves, arteriovenous leakage and other post-operative thrombosis, thromboangiitis obliterans, etc.

For oral administration, enteric-coated tablets should be taken with appropriate amount of water before meals. Dosage and frequency of medication: 1. In unstable angina (heart pain caused by coronary blood flow obstruction), the daily dose of aspirin is 75mg-300mg, and the recommended daily dose of aspirin is 100mg (equivalent to 1 tablet of aspirin (enteric-coated aspirin tablets) per day. 2. In acute myocardial infarction, the daily dose of aspirin is 100mg-160mg, and the recommended daily dose is 100mg (equivalent to 1 tablet of Bayaspirin (enteric-coated aspirin tablets) per day. 3. To prevent recurrence of myocardial infarction, the recommended daily dose of aspirin is 300mg (equivalent to 1 tablet of Bayaspirin (enteric-coated aspirin tablets) per day. 4. After arterial vascular surgery (arterial surgery or interventional surgery, such as aortic coronary artery bypass grafting, PTCA), the daily dose of aspirin is 100mg-300mg, and the recommended daily dose is 100mg (equivalent to 1 tablet of enteric-coated aspirin. 5. To prevent a one-time decrease in blood flow to the brain (TIA: transient ischemic attack) and to prevent cerebral infarction after early symptoms have appeared, the daily dose of aspirin is 30mg-300mg, and the recommended daily dose is 100mg (equivalent to 1 tablet of enteric-coated aspirin per day). 6. To reduce the risk of suspected acute myocardial infarction patients: The recommended first dose is 300mg. Chew this product and take it with warm water after meals. Do not take it on an empty stomach. This product is an enteric-coated tablet and must be swallowed whole, except when treating acute myocardial infarction. In order to quickly exert the drug effect, the first tablet should be crushed or chewed before taking. After aortic coronary artery and vein bypass grafting (ACVB), the best time to start using enteric-coated aspirin is 24 hours after surgery. Enteric-coated aspirin should be used for a long time. Please follow the doctor's advice on the period of use.

The doses generally used for antipyretic and analgesic rarely cause adverse reactions. Long-term and large-scale use of the drug (such as treatment of rheumatic fever), especially when the blood concentration of the drug is >200μg/ml, is more likely to cause adverse reactions. The higher the blood concentration, the more obvious the adverse reactions. (1) Gastrointestinal reactions such as nausea, vomiting, upper abdominal discomfort or pain (caused by the direct stimulation of the gastric mucosa by this product) (incidence rate 3% to 9%) are common, which can disappear after stopping the drug. Long-term or large-dose use may cause gastrointestinal bleeding or ulcers. (2) Central nervous system: reversible tinnitus and hearing loss occur, which often occur after a certain course of treatment and the blood concentration reaches 200-300g/L. (3) Allergic reaction: occurs in 0.2% of patients, manifested as asthma, urticaria, angioedema or shock. Most of them are susceptible people, and they quickly develop breathing difficulties after taking the drug. Severe cases can cause death, which is called aspirin asthma. Some are aspirin allergy, asthma and nasal polyps, which are often related to genetic and environmental factors. (4) Damage to liver and kidney function is related to the dosage, especially when the dosage is too large and the blood drug concentration reaches 250mu;g/ml. The damage is reversible and can be restored after stopping the drug. However, there are reports of renal papillary necrosis. (5) Symptoms of overdose or poisoning: ① Mild, namely salicylic acid reaction (salicylism), which is more common in patients with rheumatism treated with this product, manifested as headache, dizziness, tinnitus, deafness, nausea, vomiting, diarrhea, drowsiness, mental disorder, sweating, deep and rapid breathing, thirst, involuntary movements of hands and feet (more common in the elderly) and visual impairment; ② Severe, hematuria, convulsions, hallucinations, severe mental disorder, dyspnea and unexplained fever may occur; mental and respiratory disorders are more obvious in children; in case of overdose, laboratory tests may show abnormal EEG, changes in acid-base balance (respiratory alkalosis and metabolic acidosis), hypoglycemia or hyperglycemia, ketonuria, hyponatremia, hypokalemia and proteinuria.

Enteric-coated aspirin tablets are contraindicated in the following situations: 1. Allergy to aspirin or other salicylates, or any other ingredients of the drug; 2. History of asthma caused by salicylates or salicylic acid-containing substances or non-steroidal anti-inflammatory drugs; 3. Acute gastrointestinal ulcers; 4. Bleeding constitution; 5. Severe renal failure; 6. Severe liver failure; 7. Severe heart failure; 8. Co-use with methotrexate (dose 15 mg/week or more) (see Drug Interactions); 9. The last three months of pregnancy.

Precautions for children: Pediatric patients, especially those with fever and dehydration, are prone to toxic reactions. The use of this product in children with acute febrile diseases, especially influenza and chickenpox, may be associated with the development of Reye's syndrome, which is rare in China. Precautions for pregnancy and lactation: This product easily passes through the placenta. Animal experiments show that the use of this product in the first 3 months of pregnancy can cause teratogenesis, such as spina bifida, skull cleft, facial cleft, leg deformity, and incomplete development of the central nervous system, internal organs and bones. There are also reports of fetal defects in humans after the use of this product. In addition, long-term and large-scale use of this product in the last 3 months of pregnancy can prolong the pregnancy period and increase the risk of post-term labor syndrome and antepartum hemorrhage. Use in the last 2 weeks of pregnancy can increase the risk of fetal hemorrhage or neonatal hemorrhage. Long-term use of the drug in the late pregnancy may also cause the fetal ductus arteriosus to contract or close early, leading to persistent pulmonary hypertension and heart failure in the newborn. It has been reported that excessive use or abuse of this product in late pregnancy has increased the incidence of stillbirth or neonatal death (possibly due to ductus arteriosus atresia, antepartum hemorrhage or low body weight). However, the above adverse reactions have not been found in general therapeutic doses. This product can be excreted in breast milk. When lactating women take 650 mg orally, the drug concentration in breast milk can reach 173-483 μg/ml after 5-8 hours. Therefore, long-term high-dose medication may cause adverse reactions in infants. Precautions for the elderly: Elderly patients are prone to toxic reactions when taking this product due to decreased renal function.

Contraindications: Methotrexate (at a dose of 15 mg/week or more): Increases the blood toxicity of methotrexate (salicylic acid and methotrexate compete with plasma proteins for binding, reducing the renal clearance of methotrexate) (see contraindications). Use with caution: 1. Methotrexate (at a dose of less than 15 mg/week): Increases the blood toxicity of methotrexate (salicylic acid and methotrexate compete with plasma proteins for binding, reducing the renal clearance of methotrexate). 2. Ibuprofen: The combined use of ibuprofen will interfere with the irreversible inhibitory effect of aspirin on platelets. The use of ibuprofen by patients with cardiovascular risks may limit the cardiovascular protective effect of aspirin (see precautions).

Store in a cool place (below 20℃)

25 mg

60 months, do not use after the expiration date.

CSPC OUYI Pharmaceutical Co., Ltd.

• Founded in:

  2001-03-29

• Address:

  No. 88, Yangzi Road, Shijiazhuang Economic and Technological Development Zone

• Tax NO.:

  91130100601289268L

• Registered Funds:

  298 million yuan

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