Granisetron Hydrochloride Dispersible Tablets

Pharmacological action: This product is a highly selective 5-HT3 receptor antagonist, which inhibits the occurrence of nausea and vomiting by antagonizing the 5-HT3 receptors in the central chemoreceptor area and peripheral vagus nerve endings. This product has high selectivity and no side effects such as extrapyramidal reactions and excessive sedation. Toxicological studies: Acute toxicity: The median lethal dose (LD50) of a single intravenous injection of this product in mice and rats is 17-25 mg/kg and 14-16 mg/kg, respectively. Subacute and chronic toxicity tests: The maximum tolerated dose of this product in rats after continuous intravenous injection for 28 days or 13 weeks is 3.0 mg/kg and 0.5 mg/kg, respectively; the maximum tolerated dose of this product in dogs after continuous intravenous injection for 28 days or 13 weeks is 0.3 mg/kg and 0.5 mg/kg, respectively.

Granisetron Hydrochloride

This product is white or off-white tablets

Used to prevent and treat nausea and vomiting caused by tumor chemotherapy and radiotherapy.

Oral administration: The usual dosage for adults is 1 mg (1 tablet), twice a day, the first dose is taken 1 hour before chemotherapy, and the second dose is taken 12 hours after the first dose, or as directed by a doctor. No dosage adjustment is required for the elderly and those with impaired liver or kidney function.

Common side effects include headache, fatigue, fever, constipation, and occasionally transient asymptomatic increase in serum transaminase activity. These reactions are generally mild and do not require special treatment.

1. Patients who are allergic to this product or related compounds are prohibited from using this product. 2. Patients with gastrointestinal obstruction are prohibited from using this product.

Precautions for children: The efficacy and safety of the drug have not been determined. Precautions for pregnancy and lactation: Pregnant women should not use unless necessary; lactating women should use with caution and should stop breastfeeding if using this product. Precautions for the elderly: See the dosage and administration section.

Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.

Keep in a dark place and sealed. The validity period is tentatively three years.

Each tablet contains 1 mg of granisetron

36 months

Guangxi Mingjian Pharmaceutical Co., Ltd.

• Founded in:

  1989-06-12

• Address:

  No. 21, Lane 4, Minxing Road, Xiaojiang Street, Pubei County

• Tax NO.:

  914507222012232433

• Registered Funds:

  1.68 million yuan

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