Indapamide Tablets
Ingredients
The main ingredient of this product is indapamide, and its chemical name is: N-(2-methyl-2,3-dihydro-1H-indolyl)-3-sulfamoyl-4-chloro-benzamide. Its structural formula is: Molecular formula: C16H16ClN3O3S Molecular weight: 365.83
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| IndapamideIngredients |
It is a sulfonamide diuretic that works by inhibiting the reabsorption of water and electrolytes in the dilution segment of the distal renal tubular cortex. Possible mechanisms of antihypertensive effects include regulating calcium influx into vascular smooth muscle cells; stimulating the synthesis of prostaglandins PGE2 and prostaglandins PGI2; reducing vascular hypersensitivity to vasopressors, thereby inhibiting vasoconstriction. This product has little or no effect on cardiac output, heart rate and rhythm when lowering blood pressure. Long-term use of this product rarely affects glomerular filtration rate or renal blood flow. This drug does not affect the metabolism of blood lipids and carbohydrates. More |
26807-65-8 | 29 |
Appearance
This product is a sugar-coated tablet, which appears white after removing the sugar coating.
Indication
Anti-hypertensive, has the effects of dilating vascular smooth muscle and diuresis, and is used for primary hypertension.
Usage and Dosage
The usual adult dose is 1 tablet per oral administration, once a day.
Adverse Reactions
Relatively mild and short-lived, and dose-related. ⑴ Less common: diarrhea, headache, loss of appetite, insomnia, nausea, orthostatic hypotension. ⑵ Rare: allergic reactions such as rash and itching; hyponatremia, hypokalemia, and hypochloremic alkalosis.
Precautions
Patients allergic to sulfonamides Severe renal insufficiency Hepatic encephalopathy Hypokalemia In general, this drug should not be used in combination with lithium and non-antiarrhythmic drugs that can induce torsades de pointes (see Drug Interactions).
Special Population Medication
Precautions for children: Not clear yet. Precautions for pregnancy and lactation: There is no human research on the effect on pregnancy, and no problems have been found in animal studies. It is not clear whether this product is excreted into breast milk, but no problems have occurred in human use. Precautions for the elderly: The elderly are more sensitive to antihypertensive effects and electrolyte changes, and often have changes in renal function, so caution should be exercised when using this product.
Drug Interactions
① When this product is used together with adrenal cortical hormone, its diuretic and natriuretic effects are weakened; ② When this product is used together with amiodarone, it is easy to cause arrhythmia due to low blood potassium; ③ When this product is used together with oral anticoagulants, the anticoagulant effect is weakened; ④ When this product is used together with non-steroidal anti-inflammatory analgesics, the natriuretic effect of this product is weakened; ⑤ When this product is used together with dopamine, the diuretic effect is enhanced; ⑥ When this product is used together with other types of antihypertensive drugs, the antihypertensive effect is enhanced; ⑦ When this product is used together with sympathomimetics, the antihypertensive effect is weakened; ⑧ When this product is used together with lithium agents, the blood lithium concentration may increase and signs of overdose may appear; ⑨ When used together with large doses of salicylates, dehydrated patients may develop acute renal failure; ⑩ When used together with metformin, lactic acidosis is likely to occur.
Storage
Keep in a light-proof and airtight container.
Packaging Specification
2.5mg
Validity Period
24 months.
Manufacturer
Jinan Gaohua Pharmaceutical Co., Ltd.
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Founded in:
1994-12-22 -
Address:
No. 8 Panwang Road, Mingshui Economic Development Zone, Longshan Street, Zhangqiu District, Jinan City, Shandong Province -
Tax NO.:
913701812644656618 -
Registered Funds:
2.1 million yuan -
Email: