Indapamide Tablets

It is a sulfonamide diuretic that works by inhibiting the reabsorption of water and electrolytes in the dilution segment of the distal renal tubular cortex. The antihypertensive effect is unclear, and its diuretic effect cannot explain the antihypertensive effect, because the dose at which the antihypertensive effect occurs is much smaller than the dose of the diuretic effect. Possible mechanisms include the following aspects: regulating calcium influx into vascular smooth muscle cells; stimulating the synthesis of prostaglandins PGE2 and prostaglandins PGI2; reducing the hypersensitivity of blood vessels to vasopressor amines, thereby inhibiting vasoconstriction. This product has little or no effect on cardiac output, heart rate and heart rhythm when lowering blood pressure. Long-term use of this product rarely affects glomerular filtration rate or renal blood flow. This drug does not affect the metabolism of blood lipids and carbohydrates.

Indapamide

This product is a sugar-coated tablet, which appears white after removing the sugar coating.

Used to treat high blood pressure.

The usual adult dose is 1 tablet per oral administration, once a day.

Relatively mild and short-lived, and dose-related. (1) Less common are: diarrhea, headache, loss of appetite, insomnia, nausea, and orthostatic hypotension. (2) Rare are: allergic reactions such as rash and itching; hyponatremia, hypokalemia, and hypochloremic alkalosis.

Allergic to sulfonamides, severe renal insufficiency, hepatic encephalopathy or severe hepatic insufficiency, hypokalemia.

Precautions for children: This experiment was not conducted and there are no reliable references. Precautions for pregnancy and lactation: There is no human research on the effect on pregnancy, and no problems have been found in animal studies. It is not clear whether this product is excreted into breast milk, but no problems have occurred in human use. Precautions for the elderly: The elderly are more sensitive to antihypertensive effects and electrolyte changes, and often have changes in renal function, so caution must be exercised when using this product.

1. The diuretic and natriuretic effects of this product are weakened when it is used together with adrenal cortical hormones; 2. When this product is used together with amiodarone, it is easy to cause arrhythmia due to low blood potassium; 3. The anticoagulant effect of this product is weakened when it is used together with oral anticoagulants; 4. The natriuretic effect of this product is weakened when it is used together with non-steroidal anti-inflammatory analgesics; 5. The diuretic effect of this product is enhanced when it is used together with dopamine; 6. The antihypertensive effect of this product is enhanced when it is used together with other types of antihypertensive drugs; 7. The antihypertensive effect of this product is weakened when it is used together with sympathomimetics; 8. When this product is used in combination with lithium, the blood lithium concentration may increase and signs of overdose may appear; 9. When used in combination with large doses of salicylates, dehydrated patients may develop acute renal failure; 10. Lactic acidosis is prone to occur when used in combination with metformin.

Keep in a light-proof and airtight container.

2.5mg

24 months.

Yabao Pharmaceutical Group Co., Ltd.

• Founded in:

  1999-01-26

• Address:

  No. 43, Fumin Road, Ruicheng County, Yuncheng City, Shanxi Province

• Tax NO.:

  91140000701108049W

• Registered Funds:

  720,000,940 yuan

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