Cephalexin Tablets

This product is a semi-synthetic cephalosporin broad-spectrum antibiotic. The antibacterial spectrum is similar to that of cephalothin, but the antibacterial activity is poorer than that of cephalothin. This product is stable to the penicillinase produced by Staphylococcus aureus, so it has a good antibacterial effect on penicillin-resistant Staphylococcus aureus. Except for Enterococcus and methicillin-resistant Staphylococcus, most Gram-positive cocci are sensitive to this product. This product has a good antibacterial effect on Neisseria, and has antibacterial effects on some Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, and Salmonella; it has a poor effect on Haemophilus influenzae; other Enterobacteriaceae, Acinetobacter, Pseudomonas aeruginosa, and Bacteroides fragilis are resistant to this product. The mechanism of action of this product is to inhibit the synthesis of bacterial cell walls.

The main ingredient of this product is cephalexin, and its chemical name is (6R,7R)-3-methyl-7-[(R)-2-amino-2-phenylacetylamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate.

This product is a light yellow tablet with small yellow dots scattered on the surface. It is easily soluble in water and has a sweet taste.

This product is suitable for mild and moderate acute tonsillitis, pharyngitis, otitis media, sinusitis, bronchitis, pneumonia and other respiratory tract infections, urinary tract infections and skin and soft tissue infections caused by sensitive bacteria.

Put this product into warm water and drink it after it dissolves. Oral administration for adults: 0.25-0.5g once every 6 hours. The highest dose is 4g per day. For patients with simple cystitis, skin and soft tissue infections and streptococcal pharyngitis, take 500mg once every 12 hours. For children, take 25-50mg/kg per day according to body weight, once every 6 hours. For patients with skin and soft tissue infections and streptococcal pharyngitis, take 12.5-50mg/kg according to body weight, once every 12 hours.

1. Common gastrointestinal reactions: soft stool, diarrhea, stomach discomfort, loss of appetite, nausea, vomiting, heating, etc. 2. Rare allergic reactions such as rash and drug fever and nervous system reactions such as dizziness, diplopia, tinnitus, convulsions, etc. 3. Some patients with endocarditis may experience hematuria, eosinophilia and increased serum creatinine when taking this product at high doses (20-40g per day, with probenecid added), but the above reactions will disappear quickly after drug withdrawal. 4. Occasionally, serum aminotransferase increases, antiglobulin (Coombs) test is positive, granulocytopenia and pseudomembranous colitis are seen; hemolytic anemia is rare.

Patients who are allergic to this product or other cephalosporins are contraindicated.

Precautions for children: Precautions for pregnancy and lactation: This product crosses the placenta, so pregnant women should use it with caution; this product can also be excreted through breast milk. Although there are no reports of problems with the use of cephalosporins in lactating women, it is still necessary to weigh the pros and cons before using it. Precautions for the elderly:

1. Furosemide, ethacrynic acid, bumetanide and other strong diuretics, carmustine, streptozocin and other anti-tumor drugs and aminoglycoside antibiotics and other nephrotoxic drugs combined with this product may increase nephrotoxicity. 2. Clavulanic acid can enhance the antibacterial activity of this product against certain Gram-negative bacteria that are resistant to this product due to the production of beta-lactamase. 3. Probenecid can delay the excretion of this product through the kidney, extending the blood elimination half-life (t1/2?) of this product to 107 minutes; however, there are also reports that probenecid can increase the excretion of this product in bile. 4. When this product is used in combination with cholestyramine (cholestyramine), the average blood peak concentration of this product can be reduced.

Keep away from light, seal tightly and store in a cool dark place.

Calculated as C16H17N3O4S 0.25g

24 months

Beijing Jingfeng Pharmaceutical Co., Ltd.

• Founded in:

  2002-03-06

• Address:

  Building 1, Building 9-10, Building 12-13, No. 21, Xiangrui Street, Daxing Biomedicine Industry Base, Zhongguancun Science Park, Daxing District, Beijing

• Tax NO.:

  91110000736469100Q

• Registered Funds:

  475.3425 million yuan

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